J A Shadduck

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The ability to introduce carefully controlled numbers of viable cells into the anterior chamber of mouse eyes made it possible to examine the interrelationship between presentation of antigens into the anteior chamber and into conventional body sites and their synergistic/antagonistic effects on the immune system. P815 mastocytoma (DBA/2; H-2d) cells are(More)
The ability to introduce carefully controlled numbers of viable cells into the anterior chamber of mouse eyes made it possible to examine the interrelationship between presentation of antigens intracamerally and into conventional body sites and their synergistic/antagonistic effects on the immune system. P815 mastocytoma (DBA/2; H-2d) cells are syngeneic(More)
Feline leukemia virus, a naturally occurring C-type virus (oncorna virus), was injected systemically and intraocularly into fetal and newborn kittens. A light microscopy study of the resultant ocular tumor changes was carried out. One animal developed an intraocular tumor of apparent retinal origin. Eight animals showed intraocular neoplastic cell(More)
This paper described the first animal model of a virally induced uveal melanoma. Tumors developed following the injection of an RNA tumor virus, i.e., Gardner strain feline sarcoma virus, into the anterior chamber of newborn kittens. Histologically, the tumors were found to be iris and ciliary body melanomas, many of which showed invasion. The histology and(More)
Although veterinary medicine endorses high moral character and adherence to a code of ethics, to our knowledge, virtually no studies have examined the influence of veterinary medical education on the moral development of its students. Using the Kohlberg standard moral judgment interview, this study examined that relationship in a sample of 20 veterinary(More)
The humoral immune response to a virally induced feline model of human uveal melanoma was studied by examining sera from cats bearing iridal and choroidal melanomas for antibody to the feline oncornavirus-associated cell membrane antigen (FOCMA). Anti-FOCMA antibodies appeared earlier and in higher titers in cats that ultimately expressed nonprogressing(More)
The effect of enucleation of an eye containing a malignant intraocular neoplasm on the occurrence of secondary tumors was studied in cats with tumors, mainly melanomas, induced by Gardner feline fibrosarcoma virus. Enucleation of eyes containing progressively growing tumors was followed by a sharp increase in the frequency of secondary tumors. Secondary(More)
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