Learn More
Simvastatin, a hydroxy-methylglutaryl-coenzyme A reductase inhibitor intended for use as a hypocholesterolemic agent, has undergone a thorough preclinical toxicology evaluation. This review describes preclinical toxicology findings associated with simvastatin administration in animals and provides the rationale for our conclusion that these changes are not(More)
Studies of total parenteral nutrition-related infection have incorrectly relied on positive results on culture of the cannula tip to confirm the source. We undertook a prospective study of total parenteral nutrition-related infections in adult patients by obtaining blood from all total parenteral nutrition lines for pour-plate culture twice weekly and(More)
Bisphosphonates have generally few clinicaladverse effects, the most common being gastrointestinaldisturbances. It is generally believed thatbisphosphonates with a primary amine are more irritatingto the gastrointestinal tract than those withouta primary amine. The objective of this study was tocompare the gastric irritation potential of an(More)
Female albino rats were exposed to carbon monoxide in concentrations ranging from 130 to 1030 mg/m3 for a period of 40 minutes. During the last 20 minutes of exposure, the rats were subject to forced run on a flat treadmill moving at a rate of 400 m/hour. Immediately after termination of exposure, the concentration of carboxyhemoglobin and lactic acid in(More)
To assess the importance of skin flora in the pathogenesis of infection complicating total parenteral nutrition and the predictive value of positive skin cultures for the development of infection 54 patients, who received 59 courses of total parenteral nutrition, were followed up. Three times per week, at the time of dressing and line changes, the skin at(More)
Female Sprague-Dawley rats were treated with either simvastatin (a novel competitive inhibitor of HMG CoA reductase) or phenobarbital (positive control) to ascertain the possible relationship between the effects of simvastatin on hepatic metabolism and the thyroid hypertrophy and follicular cell adenomas which it produces in this strain of rat. The test(More)
5 days' exposure of rats to daily doses of 400 mg/kg body wt. of chlordiazepoxide, diazepam and oxazepam stimulated the microsomal metabolism in the liver, as evidenced by acceleration of both p-hydroxylation of aniline and hydroxylation of benzene. The effect was accompanied by an increased concentration of liver microsomal protein and by the development(More)
Determination of carbon monoxide by gas chromatography was described. Having been separated from other air components, carbon monoxide is reduced to methane in the presence of nickel catalyst and determined on the flame-ionization detector. A rectilinear dependence was found between the peak surface or height and CO concentration within 0,5-1000 ppm. The(More)