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OBJECTIVE We examined the association of fetal and newborn complications, socioeconomic status, and home environment with learning deficits as assessed between 9 and 11 years of age. STUDY DESIGN A total of 218 high-risk newborns have been assessed at 1, 4, and 9 to 11 years of age. Fetal and newborn complications included 77 newborns with growth(More)
Maturation of human fetal response to vibroacoustic stimulation was examined in 60 fetuses from 23 to 36 weeks gestational age. Subjects received vibroacoustic or no-stimulus control trials (randomly assigned) while fetal heart rate (FHR) was recorded and movement was observed on real-time ultrasound scan. Initially, at 26-28 weeks, a small FHR deceleration(More)
  • James A Low
  • The journal of obstetrics and gynaecology…
  • 2004
Studies in the research laboratory have demonstrated the complex relationship between fetal and newborn asphyxia and brain damage, a balance between the degree, duration and nature of the asphyxia and the quality of the cardiovascular compensatory response. Clinical studies would support the contention that the human fetus and newborn behave in a similar(More)
  • J A Low
  • American journal of obstetrics and gynecology
  • 1988
The diagnosis of fetal asphyxia requires a blood gas and acid-base assessment demonstrating a significant metabolic acidosis. However, the fetus may tolerate an asphyxial insult without central nervous system injury because of the fetal cardiovascular adaptation to hypoxemia. Prediction of the significance of an asphyxial insult to the fetus requires a(More)
The neuropathologic conditions in 120 perinatal deaths attributed to fetal or newborn asphyxia were examined. Central nervous system necrosis was present in 16 of these deaths. The approximate time of asphyxial insult was established by determining the duration of the process, based on the findings of neuronal necrosis, macrophage response, or an astrocyte(More)
The incidence of major and minor motor and/or cognitive deficits at 1 year of age, in 37 mature children who had experienced an intrapartum fetal asphyxial insult, was compared with the incidence of deficits at 1 year in 76 children of the control group. The incidence of both major and minor deficits was significantly greater in the group with intrapartum(More)
A total of 364 selected high-risk premature and mature infants were studied prospectively to assess the relationship between fetal-newborn complications and motor and cognitive deficits identified during the first year of life. Deficits occurred in 24 per cent of the children: 14 per cent had one or more major deficit and the other 10 per cent had one or(More)
Sixty children with biochemical evidence of intrapartum fetal hypoxia were studied to define the factors which distinguish the children with deficits from those without deficits of motor and cognitive development. Follow-up assessment included growth measures, neurological examination, Bayley Scales of Infant Development, and a modified Uzgiris and Hunt(More)
The clinical and urodynamic characteristics of 54 women with unstable urethras (falls of urethral pressures of at least 20 cm H2O) were compared with those of 171 patients with stable urethras. The unstable-urethra patients were younger and presented with an increased incidence of marked urgency and a lower incidence of genuine stress incontinence. The(More)