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- Daniel J Barry, J. A. Hartigan
- Biometrics
- 1987

The distance between homologous DNA sequences of two species is proposed to be -1/4 ln[det(P)], where P is the conditional probability matrix specifying the proportions of the various nucleotides in the second sequence, corresponding to each of the four nucleotides in the first sequence. A probability model is described which supports this choice of… (More)

- Brett R. Dunn, J. A. Hartigan, W L Mikulas
- Applied psychophysiology and biofeedback
- 1999

Electroencephalographic (EEG) recordings from 19 scalp recording sites were used to differentiate among two posited unique forms of mediation, concentration and mindfulness, and a normal relaxation control condition. Analyzes of all traditional frequency bandwidth data (i.e., delta 1-3 Hz; theta, 4-7 Hz; alpha, 8-12 Hz; beta 1, 13-25 Hz; beta 2, 26-32 Hz)… (More)

- Bruce Rannala, J. A. Hartigan
- Genetical research
- 1996

A new method is presented for estimating the rate of gene flow into island populations using the distribution of alleles in samples from a number of islands. The pseudo maximum likelihood estimator (PMLE) that we derive may be applied to species with either discrete or continuous generation times. For Wright's discrete-generation island model, the method… (More)

- Hua Qin Xie, Joel M Litersky, J. A. Hartigan, Richard Scott Jope, Gail V. W. Johnson
- Brain research
- 1998

The purpose of this study was to examine the modulation of tau phosphorylation mediated by protein kinase A, a kinase with low intrinsic activity, and by the constitutively active glycogen synthase kinase, as well as to examine the subsequent effects on tau-microtubule association in differentiated human SH-SY5Y neuroblastoma cells. Activation of protein… (More)

- Alexander I. Barvinok, J. A. Hartigan
- Random Struct. Algorithms
- 2013

We consider the set of all graphs on n labeled vertices with prescribed degrees D = (d1, . . . , dn). For a wide class of tame degree sequences D we prove a computationally efficient asymptotic formula approximating the number of graphs within a relative error which approaches 0 as n grows. As a corollary, we prove that the structure of a random graph with… (More)

- J. A. Hartigan, Gail V. W. Johnson
- The Journal of biological chemistry
- 1999

Calcium is a universal intracellular signaling molecule. Through variations in both the amplitude and frequency of intracellular calcium increases, the same calcium ion can elicit different responses. In this report, we investigated the effect of a calcium transient, lasting 2-5 min, on alterations in the phosphorylation state of the cytoskeletal protein,… (More)

- J. A. Hartigan, Wen Cheng Xiong, Gail V. W. Johnson
- Biochemical and biophysical research…
- 2001

Glycogen synthase kinase 3beta (GSK3beta) is a Ser/Thr kinase that is involved in numerous cellular activities. GSK3beta is activated by tyrosine phosphorylation. However, very little is known about the tyrosine kinases that are responsible for phosphorylating GSK3beta. In this report, we investigated the ability of the calcium-dependent tyrosine kinase,… (More)

- Liza A. Pon, J. A. Hartigan, NANETTE R. ORME-JOHNSON
- The Journal of biological chemistry
- 1986

Two-dimensional gel electrophoresis was used to monitor proteins synthesized in unstimulated control and in adrenocorticotropic hormone (ACTH)- or cAMP-stimulated rat adrenal cells. Four proteins, which have similar proteolytic peptide maps, have been identified. The two found primarily in unstimulated cells are referred to as pb and pa, where pb is the… (More)

- J. A. Hartigan
- Annual review of biophysics and bioengineering
- 1973

- Gail V. W. Johnson, J. A. Hartigan
- Journal of Alzheimer's disease : JAD
- 1999

Tau is a microtubule-associated protein that, in a hyperphosphorylated form, comprises the main component of the paired helical filaments and neurofibrillary tangles found in Alzheimer's Disease (AD) brain. It is therefore important to understand the normal functioning and processing of tau protein, and the abnormal posttranslational processing of tau in AD… (More)