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The introduction of Java has been heralded as a revolution in network computing. Certainly, machine and operating system independent applets ittering through the Internet promised to jazz up web surrng; but could they be used to advantage for distributed comput-ing? The authors had encountered substantial problems in implementing a distributed revision(More)
In mice, homozygous for the retinal degeneration slow (rds) gene, the photoreceptor cells lack outer segment disc structures, contain low amounts of rhodopsin, and degenerate slowly, while the inner retinal layers remain intact. The electroretinogram (ERG) from 1-month-old mutant mice shows a lower than normal amplitude but the time-to-peak is normal. The(More)
Chromosomal region 18q21 is frequently deleted in colorectal cancer (CRC) and is associated with poor prognosis. Potential tumor suppressor mechanisms altered by 18q21 deletion include mediation of TGFbeta signaling by SMADs. Following the definition of SMAD4 deletion as a negative predictive marker for chemotherapy benefit in patients with CRC, we aimed to(More)
Remote method invocation in Java RMI allows the flow of control to pass across local Java threads and thereby span multiple virtual machines. However, the resulting distributed threads do not strictly follow the paradigm of their local Java counterparts for at least three reasons: Firstly, the absence of a global thread identity causes problems when(More)
Revision control has long been a standard part of software development. With the enormous expansion of the Internet and its increasing use as a means of communicating among geographically dispersed software developers, the need for distributed version control over the Internet has become acute. In order to address this need, the authors have developed a(More)
BACKGROUND Improved risk stratification of early colorectal cancer might help to better select patients for adjuvant treatment. Alterations in the transforming growth factor-beta (TGF-beta) pathway have frequently been found in colorectal cancer, but their impact on prognosis remains controversial. We therefore analyzed two transcriptional corepressors of(More)
Adjuvant chemotherapy reduces the incidence of distant metastasis and increases survival of patients with colorectal cancer. However, predictive markers are needed to define subsets of patients with stage II and III disease that may benefit from adjuvant treatment. A secreted member of the TNF receptor superfamily, the decoy receptor 3 (DcR3), was reported(More)
1. Glomerular blood flow distribution was studied in seventy-eight new-born mongrel dogs aged 1-40 days by measuring the distribution of radioactive labelled microspheres within the kidney.2. The microsphere technique was found to be a valid indicator of glomerular blood flow distribution for the new-born dog since (a) the spheres were completely extracted(More)