Jürgen Hartinger

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Integral membrane proteins, particularly those with more than one transmembrane domain, have traditionally been difficult to separate by two-dimensional electrophoretic methods. Here we report the adaptation of a previously published procedure [D. E. Macfarlane (1989) Anal. Biochem. 176, 457-463] for the analytical and semipreparative separation of membrane(More)
Glutamate, the major excitatory neurotransmitter of the mammalian central nervous system, is stored in synaptic vesicles and released by exocytosis upon depolarization of the presynaptic nerve terminal. Synaptic vesicles possess an active glutamate-specific transporter that is driven by an electrochemical proton gradient across the vesicle membrane and(More)
A novel membrane protein from rat brain synaptic vesicles with an apparent 29,000 Mr (p29) was characterized. Using monospecific polyclonal antibodies, the distribution of p29 was studied in a variety of tissues by light and electron microscopy and immunoblot analysis. Within the nervous system, p29 was present in virtually all nerve terminals. It was(More)
The gamma-aminobutyric acid transporter of rat brain synaptic vesicles was reconstituted in proteoliposomes, and its activity was studied in response to artificially created membrane potentials or proton gradients. Changes of the membrane potential were monitored using the dyes oxonol VI and 3,3'-diisopropylthiodicarbocyanine iodide, and changes of the H+(More)
In this article we investigate Quasi-Monte Carlo methods for multidimensional improper integrals with respect to a measure other than the uniform distribution. Additionally, the integrand is allowed to be unbounded at the lower boundary of the integration domain. We establish convergence of the Quasi-Monte Carlo estimator to the value of the improper(More)
The minimum distance of QMC sample points to the boundary of the unit cube is an important quantity in the error analysis of QMC integration for functions with singularities. Sobol’ and recently Owen show that the Sobol’ and Halton sequences avoid a hyperbolically shaped region around the corners of the unit cube. We extend these results in two ways. First,(More)
For the classical Cramér-Lundberg risk model, a dividend strategy of threshold type has recently been suggested in the literature. This strategy consists of paying out part of the premium income as dividends to shareholders whenever the free surplus is above a given threshold level. In contrast to the well-known horizontal barrier strategy, the threshold(More)
Pricing of catastrophe bonds leads to integrals with discontinuous and formally infinite-dimensional integrands. We investigate the suitability of QuasiMonte Carlo methods for the numerical evaluation of these integrals and develop several variance-reduction algorithms. Furthermore, the performance of Quasi-Monte Carlo sequences for asymptotically efficient(More)
In the last decade considerable practical interest, e.g. in credit and insurance risk or telecommunication applications, as well as methodological challenges caused intensive research on estimation of rare event probabilities. This article aims to show that recently developed rare event estimators are especially well-suited for a quasiMonte Carlo framework(More)
Recently, the analysis of quasi-Monte Carlo (QMC) sampling of integrands with singularities gained considerable interest. In this setting error bounds for QMC integration, in addition to discrepancy, include a measure how well the singularities are avoided by the utilized sequences. The article aims to generalize results for the corner avoidance of the(More)