Jürgen Graf

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Aspect oriented programming has been proposed as a way to improve modularity of software systems by allowing encapsulation of cross-cutting concerns. To do so, aspects specify where new functionality should apply using pointcuts. Unfortunately expressions written using todays mainstream pointcut languages are fragile, as non-local changes may easily change(More)
In liver tissue matrix metalloproteinases (MMPs) and their specific inhibitors (tissue inhibitors of metalloproteinases, TIMPs) play a pivotal role in both, fibrogenesis and fibrolysis. The current knowledge of the pathophysiology of liver fibrogenesis with special emphasis on MMPs and TIMPs is presented. A systematic literature search was conducted. All(More)
OBJECTIVE To assess long-term survival, health-related quality of life, and associated costs 5 yrs after discharge from a medical intensive care unit. DESIGN Prospective cohort study. SETTING Medical intensive care unit of a German university hospital. PATIENTS Three hundred and three consecutive patients with predominantly cardiovascular and(More)
We present the JOANA (Java Object-sensitive ANAlysis) framework for information flow control (IFC) of Java programs. JOANA can analyze a given Java program and guarantee the absence of security leaks, e.g. that a online banking application does not send sensitive information to third parties. It applies a wide range of program analysis techniques such as(More)
Objective: Evaluation of resource use and costs of a medical intensive care unit (ICU) utilising the simplified Therapeutic Intervention Scoring System (TISS-28). Design: Prospective observational study. Setting: Medical ICU of a tertiary care centre. Patients: Consecutive patients with an ICU length of stay (LOS) more than 24 h. Interventions: Over a 3(More)
OBJECTIVES The goal of this study was to determine if brain natriuretic peptide (BNP) levels are associated with exercise capacity in patients with chronic heart failure (HF). BACKGROUND Plasma levels of BNP are increased subject to the degree of systolic and diastolic left ventricular dysfunction in patients with chronic HF. Exercise testing is useful to(More)
OBJECTIVE Assessment of health-related quality of life before, 1 month after, and 9 months after an intensive care unit stay using an established generic instrument, the Medical Outcome Survey Short Form-36 (SF-36). DESIGN Prospective, observational study. SETTING University hospital medical intensive care unit. PATIENTS Two hundred forty-five(More)
BACKGROUND Plasma levels of brain natriuretic peptide (BNP) are increased in patients with left heart failure. In patients with severe pulmonary embolism (PE), primary right ventricular (RV) dysfunction is frequent. Little is known about BNP secretion in acute RV failure. METHODS We prospectively studied 50 consecutive patients with confirmed PE (age(More)
BACKGROUND The purpose of the study was to examine hemodynamic parameters and intravascular volume in a porcine model in the presence of intra-abdominal hypertension (IAH) lasting for 24 hours. METHODS Twelve pigs (52.5 +/- 4.9 kg) were studied over a period of 24 hours. In six animals, the intra-abdominal pressure was increased to 30 mm Hg via carbon(More)
1. The thiazolidinedione compound, troglitazone, enhances insulin action and reduces plasma glucose concentrations when administered chronically to type 2 diabetic patients. 2. To analyse to what extent thiazolidinediones interfere with liver function, we examined the acute actions of troglitazone (0.61 and 3.15 microM) on hepatic glucose and lactate(More)