Jürgen Engel

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Agrin is a key organizer of acetylcholine receptor (AChR) clustering at the neuromuscular junction. The binding of agrin to laminin is required for its localization to synaptic basal lamina and other basement membranes. The high-affinity interaction with the coiled-coil domain of laminin is mediated by the N-terminal domain of agrin. We have adopted a(More)
This paper introduces the subject of my PhD thesis, a framework for pattern-based modeling, generation and usability evaluation of interactive systems. It describes the structural aspects of HCI pattern languages and how such languages and patterns for various modeling stages (e.g. task modeling) and abstraction levels can be exploited to automate part of(More)
Modeling and building interactive user interfaces (UI) typically requires the skills of software developers and HCI experts who cooperate with platform and marketing experts in order to arrive at solutions with the required software quality, usability, and user experience. The combination of model-driven user interface development practices with(More)
Agrin is a key organizer for postsynaptic differentiation at the neuromuscular junction (NMJ). This activity requires the binding of agrin to the synaptic basal lamina via its N-terminal (NtA) domain. It has been suggested that this binding is mediated by conserved amino acids in the gamma 1 chain of laminin. Here, we report the crystal structure of chicken(More)