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Unraveling the protein targets of vancomycin in living S. aureus and E. faecalis cells.

• Jürgen Eirich, Ronald Orth, Stephan A Sieber
• Journal of the American Chemical Society
• 2011

Vancomycin is a potent glycopeptide antibiotic that has evolved to specifically bind to the D-Ala-D-Ala dipeptide termini of nascent peptidoglycans. Although this mode of action is well established,… (More)

Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy.

• Jürgen Eirich, Jens L. Burkhart, +5 authors Stephan A Sieber
• Molecular bioSystems
• 2012

Microtubules (mt) are highly dynamic polymers composed of alpha- and beta-tubulin monomers that are present in all dividing and non-dividing cells. A broad variety of natural products exists that are… (More)

A new ground state single electron donor for excess electron transfer studies in DNA.

• Christian Trindler, Antonio Manetto, Jürgen Eirich, Thomas Carell
• Chemical communications
• 2009

A new photoinducible single electron donor has been developed, which, when linked to thymidine, is shown to be an efficient ground state reducing agent in DNA; the donor can be activated at… (More)

Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopyw

• Jürgen Eirich, Jens L. Burkhart, +5 authors Stephan A Sieber
• 2012

Microtubules (mt) are highly dynamic polymers composed of alphaand beta-tubulin monomers that are present in all dividing and non-dividing cells. A broad variety of natural products exists that are… (More)

A small molecule inhibits protein disulfide isomerase and triggers the chemosensitization of cancer cells.

• Jürgen Eirich, Simone Braig, +9 authors Angelika M. Vollmar
• Angewandte Chemie
• 2014

Resistance to chemotherapeutic agents represents a major challenge in cancer research. One approach to this problem is combination therapy, the application of a toxic chemotherapeutic drug together… (More)

Driving Protein Conformational Changes with Light: Photoinduced Structural Rearrangement in a Heterobimetallic Oxidase.

• Pearson T Maugeri, Julia J Griese, +5 authors Hannah S Shafaat
• Journal of the American Chemical Society
• 2018

The heterobimetallic R2lox protein binds both manganese and iron ions in a site-selective fashion and activates oxygen, ultimately performing C-H bond oxidation to generate a tyrosine-valine… (More)

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