Jürgen Biscoping

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Protein binding of prilocaine was investigated in vitro under various conditions of changing pH, temperature and total plasma concentration by means of HPLC with UV-detection and ultrafiltration. Whereas changes in temperature (25 degrees C-40 degrees C) and pH (pH 5-pH 10) influenced protein binding markedly, rising plasma concentrations up to 16(More)
The use of chemical substances to prevent or treat local pain had its origin in South America. It was known that central nervous system stimulation occurred among the natives of Peru who chewed the leaves of an indigenous plant (Erythroxylon coca). Circumoral numbness was believed to have occurred as a by-product of this custom. Attempts to isolate the(More)
This study was undertaken to develop a time- and cost-effective method for the detection of lidocaine, mepivacaine, prilocaine, bupivacaine, and etidocaine by HPLC/UV. The chromatographic system consisted of a C18-column (300 x 3.9 mm) for reversed-phase chromatography and a mobile phase of 30% acetonitrile and 70% 0.05 M sodium phosphate buffer. For the(More)
UNLABELLED The aim of our study was to compare epidural anesthesia and analgesia (EDA) with ropivacaine versus general anesthesia followed by IV patient-controlled analgesia with morphine (GA/PCA) after hip replacement regarding pain, side effects, and discharge from the postanesthesia care unit. After ethics committee approval, randomization, and informed(More)
Technische Gegebenheiten der MAT-Geräte stehen auch heute noch der Aufbereitung und Konzentrierung „geringer“ Blutvolumina (<300 ml) entgegen. Es wurde untersucht, ob eine einfache technische Modifikation bei kleinen Blutvolumina die Anwendung der MAT zur Fremdbluteinsparung bei Kindern ermöglicht. Hierzu wurde bei 15 kinderorthopädischen Eingriffen am(More)
The emergence of resistance during therapy and the efficacy of different antibiotic therapy regimens were studied in 38 intensive care patients suffering from pulmonary infections caused byEnterobacter cloacae. Every three days a fresh isolate was obtained from each patient and tested in vitro for susceptibility to 16 antibiotics by determination of the(More)
An impairment of cortisol synthesis can be assumed for the new antimycotic fluconazole based on its chemical structure (triazole derivative) and mechanism of action (inhibition of ergosterol synthesis). In healthy volunteers, however, no influence on steroid hormone production could be found. The present study was undertaken to clarify whether this is also(More)
We report on a 17-year-old boy with H-H-H-syndrome (hyperornithinaemia, hyperammonaemia, homocitrullinuresis), an inborn disorder of the urea cycle, who had to undergo osteo-synthesis of a fractured upper leg. Pathophysiological aspects of this rare syndrome as well as possible recommendations for the anaesthesiological management are discussed.
The prosthetic supply of the hip-joint may be accompanied by the problem of venous air embolism. By including 53 orthopaedic patients having undergone total hip replacement, the influence of bone-cement as well as of the different anaesthetic techniques on the frequency of embolic phenomenons was investigated. Embolism was determined as an abrupt decrease(More)