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- Jenö Reiczigel, Zsolt Abonyi-Tóth, Júlia Singer
- Computational Statistics & Data Analysis
- 2008

- Thomas Jaki, John-Philip Lawo, Martin J Wolfsegger, Julia Singer, Peter Allacher, Frank Horling
- Journal of pharmaceutical and biomedical analysis
- 2011

Biotechnology derived therapeutics may induce an unwanted immune response leading to the formation of anti-drug antibodies (ADA). As a result the efficacy and safety of the therapeutic protein could be impaired. Neutralizing antibodies may, for example, affect pharmacokinetics of the therapeutic protein or induce autoimmunity. Therefore a drug induced… (More)

- Julia Singer
- Statistics in medicine
- 2005

For binary matched-pairs data, this article discusses interval estimation of the difference of probabilities and an odds ratio for comparing 'success' probabilities. We present simple improvements of the commonly used Wald confidence intervals for these parameters. The improvement of the interval for the difference of probabilities is to add two… (More)

- J Singer
- Statistics in medicine
- 1997

This paper contains a short generalization of a known method for sample size determination in the case of more than two parallel groups. The term 'set of allocation ratios' corresponding to the allocation ratio from the two-group design is defined. A formula using these ratios to determine the non-centrality parameter of the F distribution is deduced. It is… (More)

- J Singer
- Statistics in medicine
- 2001

The usual methods of sample size determination which assume the homogeneity of within-group variances are not sufficiently robust against the violation of this assumption. A method using Satterthwaite's correction for unequal variances is given. It is shown that in the case of unequal variances the minimum total sample size is attained when the allocation… (More)

- L Tomori, L Vereczkey, T Past, J Singer, S Mészáros
- Acta pharmaceutica Hungarica
- 1992

A single-dose, "crossover" bioequivalence study was conducted in healthy volunteers by comparing sulpiride serum levels after oral administration of the Test Product Sulpiride (200 mg) (GYKI-Alkaloida) in fasting subjects with those produced after oral administration of a marketed reference product (200 mg) (Delagrange Co., France). Statistical comparisons… (More)

- Julia Singer
- Statistics in medicine
- 2010

The influence of molecular structure on the mechanical properties of self-assembled 1,3,5-benzenetrisamide nanofibers is investigated. Three compounds with different amide connectivity and different alkyl substituents are compared. All the trisamides form well-defined fibers and exhibit significant differences in diameters of up to one order of magnitude.… (More)

- L Vereczkey, J Singer
- Acta pharmaceutica Hungarica
- 1997

The authors have investigated the characteristics of one of the basic equations of pharmacokinetics, Bateman's equation in the function of the differences between the absorption and elimination constants.

- Júlia Singer
- Orvosi hetilap
- 2003

Two diagnostic procedures with binary outcomes are usually compared by Cohen's kappa coefficient of agreement. If the results of the two procedures are completely identical on a sample and so kappa equals to 1, the precision of the estimate can not be computed with the usual formulae and statistical softwares. A formula for variance which is valid in this… (More)