Jørgen Krohn

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PURPOSE The purpose of this study was to evaluate the role of photopic full-field electroretinography (ERG) and retinal thickness measurements by spectral-domain optical coherence tomography (SD-OCT) in the assessment of disease severity in type 1 diabetic retinopathy. METHODS A population-based cohort of 151 patients with type 1 diabetes underwent a(More)
PURPOSE To characterize the role of the endothelin system in the blood flow control of the optic nerve head and of the choroid in humans. METHODS Two studies were performed in healthy subjects. Study 1 was a randomized, placebo-controlled, double-masked, balanced, two-way crossover design and study 2 a three way-way crossover design. In study 1 twelve(More)
PURPOSE We analyzed the topography of proliferative diabetic retinopathy (PDR), and visualized the distribution of neovascularization of the optic disc (NVD) and elsewhere in the retina (NVE). METHODS The study included 174 eyes of 106 patients with early PDR. Data on the size and location of 391 NVE and 73 NVD were converted into a database of(More)
We describe two Norwegian children with fascioscapulohumeral muscular dystrophy in whom Coats' disease, deafness, mental retardation and possible epilepsy were the presenting features. The children have a 4q35 deletion giving a small residual repeat fragment that they have inherited from their father who is a mosaic. Fundal changes consistent with bilateral(More)
PURPOSE The purpose of this study was to determine the feasibility of using Cerenkov luminescence imaging (CLI) to facilitate plaque placement during episcleral brachytherapy of intraocular tumors. METHODS Ruthenium-106 (Ru-106) decays to rhodium-106, which in turn emits high-energy beta particles. When the electrons propagate through the eyewall, the(More)
PURPOSE The aims of this study were to use transscleral optical spectroscopy to analyze normal and tumor-infiltrated areas of enucleated human eyes, and to characterize the spectral properties of uveal melanomas in relation to various morphological features. METHODS Nine consecutive eyes enucleated for uveal melanoma were examined by transscleral(More)
The purpose of this study was to investigate how the geometry of a fiber optic probe affects the transmission and reflection of light through the scleral eye wall. Two geometrical parameters of the fiber probe were investigated: the source-detector distance and the fiber protrusion, i.e. the length of the fiber extending from the flat surface of the fiber(More)
OBJECTIVE To analyse the topographical distribution of choroidal naevi and to visualise their location in the ocular fundus. METHODS Data on the size and location of 210 choroidal naevi were converted into a database of two-dimensional retinal charts by means of computer-drawing software. The geometric centre of each lesion was entered into corresponding(More)
In any given phase of the age process, the rates of synthesis and degradation of collagen and other macromolecules are diversely influenced by changes in the respective enzyme activities. This naturally affects and reflects the contents of the intracellular as well as extracellular macromolecules. In our studies, the total contents of desoxyribonucleic acid(More)
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