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Monitoring and Modeling of the Reaction Dynamics in the Valine/Leucine Synthesis Pathway in Corynebacterium glutamicum
The intracellular concentrations of the valine and leucine pathway intermediates in a Corynebacterium glutamicum strain were measured during a transient state. The data were obtained by performing aExpand
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Modeling metabolic networks in C. glutamicum: a comparison of rate laws in combination with various parameter optimization strategies
TLDR
We investigate the modeling process using multiple kinetic equations together with various parameter optimization methods for a well-characterized example network, the biosynthesis of valine and leucine in C. glutamicum and derive seven dynamic models based on generalized mass action, Michaelis-Menten and convenience kinetics as well as the stochastic Langevin equation. Expand
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The identification of enzyme targets for the optimization of a valine producing Corynebacterium glutamicum strain using a kinetic model
The enzyme targets for the rational optimization of a Corynebacterium glutamicum strain constructed for valine production are identified by analyzing the control of flux in the valine/leucineExpand
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Benchmarking evolutionary algorithms on convenience kinetics models of the valine and leucine biosynthesis in C. glutamicum
TLDR
An important problem in systems biology is parameter estimation for biochemical system models. Expand
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Comparing various evolutionary algorithms on the parameter optimization of the valine and leucine biosynthesis in corynebacterium glutamicum
TLDR
Parameter estimation for biochemical model systems has become an important problem in systems biology. Expand
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Metabolic egineering of the valine pathway in corynebacterium glutamicum : analysis and modelling
The functionality of the intracellular reaction network in a Corynebacterium glutamicum valine production strain was investigated with special focus on the valine / leucine biosynthesis pathway. TheExpand
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CHAPTER 14:Development of Processes for the Production of Bulk Chemicals by Fermentation at Industrial Scale – An Integrated Approach
A large number of bulk chemicals that are currently produced by petrochemical processes can potentially be produced from renewable resources by fermentation. The diversity of enzymes in nature allowsExpand