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OBJECTIVE To evaluate efficacy and safety of clobazam, a 1,5-benzodiazepine, as adjunctive therapy for Lennox-Gastaut syndrome (LGS). METHODS Patients aged 2-60 years were randomized to placebo or clobazam 0.25, 0.5, or 1.0 mg/kg/day. Study consisted of 4-week baseline, 3-week titration, and 12-week maintenance phases, followed by a 2- or 3-week taper or(More)
— This paper deals with the concept of how to integrate results of multi physics investigation of 3D stacks into modern comprehensive 3D data structures. Beside a description of modern 3D data structures and methods for floorplanning and Place&Route, approaches for multi physics modeling are introduced. The extension of the layout optimization process by(More)
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