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A theory is developed for estimating the three-dimensional (3-D) variance of a 3-D image reconstructed from projections by weighted backprojection. The theory is applicable for any data-collection schemes that produce partially redundant sampling of the angular space. The particular data collection considered here, the single-exposure random-conical scheme,(More)
A previously developed theory of three-dimensional (3-D) variance estimation [J. Opt. Soc. Am. A 12, 2615-2627 (1995)] is applied to the structural study of a hemocyanin-Fab complex with the electron microscope. The precise locations of structurally variable regions of the macromolecule are determined from the 3-D variance maps. The structural differences(More)
Our goal is to develop intelligent molecular diagnostic systems (IMDS) that can analyze liquid samples that contain a variety of biochemical compounds. In order to analyze the liquid samples we use dedicated microarrays. At this stage, these are basically miniaturized micro titer plates. Typical dimensions of a well are 200 x 200 x 20 µm 3. These dimensions(More)
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