Jörgen Boëthius

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A head-positioning device allowing accurate position transference between computed tomography and positron emission tomography is described. A base plate is fixed to the patient's head through either an individual mold or screws into the calvarium. This base plate fits onto the headholders of the two devices, thus ensuring that scans are taken at the same(More)
Thalamotomy aiming at the CM-Pf complex and using stereotactic gamma irradiation has been performed in a series of 52 patients with severe pain due to malignancy. Lesions were produced either contra- or ipsilaterally to the side of the pain as well as bilaterally. Eight patients experienced good pain relief, 18 had moderate relief, and in 24 the operation(More)
OBJECT The authors report on the follow-up studies in patients treated at the Karolinska Hospital to evaluate the efficacy of gamma knife radiosurgery (GKS) for pilocytic astrocytoma. METHODS Twelve male and seven female patients were treated (mean age 10.6 years [range 2-60 years]). Sixteen of these patients were children in whom GKS was performed to(More)
A head fixation system is described enabling exact transfer of positions between neuroradiological and therapeutic procedures. The key item of the system is a base plate that is rigidly attached to the patient's head, either by a plastic mould or screws onto the calvarium. The base plate may easily and accurately be attached to diagnostic or therapeutic(More)
This report presents the results of a phase I trial of the value of human leucocyte interferon-alpha in the treatment of glioblastoma. Twelve patients entered the trial. In one case we believe that the patient benefitted from the interferon treatment. CT scans of patients on interferon did not reveal the true extent of the tumorous tissue.
Tissue samples from 20 patients with various intracranial tumors and one case of cerebral contusion were analyzed for the cytosolic glucocorticoid-receptor concentration using isoelectric focusing in slabs of polyacrylamide gel. It is pointed out that the clinical response to dexamethasone in brain edema associated with various intracranial lesions is, to(More)
Electrical stimulation of the periventricular and periaqueductal gray matter via a percutaneous electrode appears to be a useful method for relieving cancer pain with midline and bilateral distribution. Due to the nondestructive character and the minor surgical risks involved in this procedure it may be tried before considering bilateral cordotomy or(More)
The purpose of this study was to fabricate and investigate amsacrine containing polymeric rods for use in interstitial chemotherapy of malignant glioma. Ethylene vinyl acetate copolymer (EVAc) rods containing 40% amsacrine (AMSA) were fabricated successfully with an extrusion method. In vitro kinetic studies revealed a high level of reproducibility of the(More)
This study was carried out in order to obtain data on the relation between tumour structures seen in computer tomograms and the corresponding histopathology and cytology. Nine consecutive patients were studied, and stereotactic biopsies were obtained from sites determined on contrast enhanced computer tomograms. Biopsies were obtained from tumour areas with(More)