Jörg Thömmes

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Based on an integrated approach of genetic engineering, fermentation process development, and downstream processing, a fermentative chymotrypsinogen B production process using recombinant Pichia pastoris is presented. Making use of the P. pastoris AOX1-promotor, the demand for methanol as the single carbon source as well as an inducer of protein secretion(More)
Keywords: Data-based modeling Elastic net Lasso Monte Carlo methods Biopharmaceutical manufacturing Regularization methods a b s t r a c t Biopharmaceutical manufacturing involves multiple process steps that can be challenging to model. Oftentimes, operating conditions are studied in bench-scale experiments and then fixed to specific values during(More)
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