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The purpose of this study was to evaluate the diagnostic efficacy of magnetic resonance (MR)-guided biopsy of focal liver lesions within a short, wide-bore 1.5-T MR system and to determine the duration and accuracy of needle placement using MR fluoroscopy guidance in 25 patients. Accuracy of needle placement was evaluated in two orthogonal planes, and the(More)
The osteoblastic response (OR) phenomenon as a healing reaction during effective chemotherapy-defined by the appearance of new osteoblastic bone lesions while disease response in other tumor sites was well documented-has previously been described for breast and prostate cancer. The purpose of this study was to investigate this phenomenon that could(More)
PURPOSE To evaluate MR fluoroscopy in a short, wide-bore 1.5T MRI suitable for near real-time biopsy guidance. MATERIALS AND METHODS A total of eight consecutive patients underwent MR-guided core biopsy in a 1.5T system with a 70 cm bore diameter. A total of five biopsies were performed in focal liver lesions, three biopsies in soft-tissue tumors. Before(More)
PURPOSE To determine the accuracy of dual-modality positron emission tomographic (PET)-computed tomographic (CT) imaging, as compared with PET alone and CT alone, in the staging of non-small cell lung cancer (NSCLC). MATERIALS AND METHODS Twenty-seven patients with NSCLC underwent staging with combined fluorine 18 fluorodeoxyglucose PET and CT. CT, PET,(More)
UNLABELLED This study was performed to evaluate a possible artifact related to the administration of intravascular contrast agent in dual-modality PET/CT imaging. METHODS Thirty oncology patients underwent whole-body PET/CT. CT images, which were collected in the presence of intravenous and oral iodinated contrast agent, were used for PET attenuation(More)
3018 Background: Growth factor signaling through EGFR drives tumor proliferation, motility, angiogenic stimulation, and protects the cells from stress induced apoptosis. EMD 72000 is a humanized monoclonal anti-EGFR IgG1 antibody that blocks ligand binding, EGFR signaling, induces receptor downregulation, and potentially participates in antibody-dependent(More)
PURPOSE To determine the value of multiplanar and volume-rendered modes of analysis versus axial imaging for the optimal placement of probes in spiral image computed tomography (CT)-guided radiofrequency (RF) ablation of liver lesions. MATERIALS AND METHODS Thirty-two malignant hepatic lesions in 21 patients with hepatocellular carcinoma (n = 10) or(More)
UNLABELLED Standard application of CT intravenous contrast agents in combined PET/CT may lead to high-density artifacts on CT and attenuation-corrected PET. To avoid associated diagnostic pitfalls, we designed and compared different intravenous contrast injection protocols for routine whole-body PET/CT. METHODS Whole-body PET/CT included a topogram and a(More)
PURPOSE Co-registration accuracy in combined whole-body (WB) PET/CT imaging is impaired by respiration-induced mismatches between the CT and the PET. Furthermore, PET/CT misregistration may bias the PET tracer distribution following CT-based attenuation correction (CT-AC). With the introduction of multi-row CT technology of up to 16 detector rows into(More)
PURPOSE In this prospective study we applied both the bidimensional WHO method and the unidimensional RECIST method in treatment follow-up of solid tumors. MATERIAL AND METHODS Computed tomography was performed in 80 patients before and after one chemotherapy cycle: 20 patients each with lung cancer, lymphoma, and metastases of the lung and the liver. In(More)