Jörg Rudolph

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The amino acid L-glutamate is a major excitatory neurotransmitter that is involved in many CNS functions, including learning, memory, long-term potentiation, and synaptic plasticity. Acute exposures to ethanol (50 to 200 mM) have been shown to inhibit NMDA receptor responses, whereas chronic exposure to ethanol leads to adaptive supersensitivity thought to(More)
Excessive oxidative radical production has been implicated in a variety of neurodegerative processes including NMDA (N-methyl-D-aspartate) mediated excitotoxicity. To determine the relationship of oxidation to NMDA-receptor mediated neuronal death, we exposed rat primary cortical neuronal cultures to ferrous sulfate and the fluorescent dyes(More)
Glutamate mediated excitotoxicity is a major area of experimentation due to the potential for prevention of morbidity and brain damage associated with stroke and brain trauma. We have developed a simple rapid method to study excitotoxicity in primary cortical neuronal cultures using propidium iodide (PI) fluorescence read by a multiwell fluorescence(More)
Excessive oxidative radical formation has been implicated in a number of neurodegenerative processes, including glutamate-N-methyl-D-aspartate (NMDA)-mediated excitotoxicity. Previous studies have suggested that the formation of reactive oxygen species (ROS) during NMDA exposure is involved in triggering the excitotoxic cascade. Chronic exposure of primary(More)
Going beyond the usual determination of the frequency-resolved power spectrum of an electrical noise signal, we implement a setup for the determination of a frequency-resolved two-dimensional correlation spectrum. We demonstrate measurements of two-dimensional correlation spectra with sampling rates up to 180 MSamples/s and real-time numerical evaluation(More)
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