Jörg P. Müller

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In the past, research on agent-oriented software engineering had been widely lacking touch with the world of industrial software development. Recently, a cooperation has been established between the Foundation of Intelligent Physical Agents (FIPA) and the Object Management Group (OMG) aiming to increase acceptance of agent technology in industry by relating(More)
agent types and agent interfaces, and generic agent types. Single, multi, and dynamic inheritance can be applied for states, actions, methods, and message handling. Associations are usable to describe, e.g., agent A uses the services of agent B to perform a task (e.g. client, server), with some cardinality and roles. Aggregation and composition show, e.g.,(More)
The Mars system is described which models cooperative scheduling within a society of shipping companies as a multiagent system. Emphasis is placed on the functionality of the system as a whole | the solution of the global scheduling problem emerges from local decision-making and problem-solving strategies. An extension of the contract net protocol is(More)
In the past, research on agent-oriented software engineering had been widely lacking touch with the world of industrial software development. Recently, a cooperation has been established between the Foundation of Intelligent Physical Agents (FIPA) and the Object Management Group (OMG) aiming to increase acceptance of agent technology in industry by relating(More)
Most bacterial proteins destined to leave the cytoplasm are exported to extracellular compartments or imported into the cytoplasmic membrane via the highly conserved SecA-YEG pathway. In the present studies, the subcellular distributions of core components of this pathway, SecA and SecY, and of the secretory protein pre-AmyQ, were analysed using green(More)
The mechanism of cell transformation by Fms-like tyrosine kinase 3 (FLT3) in acute myeloid leukemia (AML) is incompletely understood. The most prevalent activated mutant FLT3 ITD exhibits an altered signaling quality, including strong activation of the STAT5 transcription factor. FLT3 ITD has also been found partially retained as a high-mannose precursor in(More)
Fms-like tyrosine kinase 3 (FLT3) plays an important role in hematopoietic differentiation, and constitutively active FLT3 mutant proteins contribute to the development of acute myeloid leukemia. Little is known about the protein-tyrosine phosphatases (PTP) affecting the signaling activity of FLT3. To identify such PTP, myeloid cells expressing wild type(More)
The objective of this paper is twofold. In its ®rst part, we survey the state of the art in research on agent architectures. The architecture of an agent describes its modules and capabilities, and how these operate together. We structure the ®eld by investigating three important research threads, i.e. architectures for reactive agents, deliberative agents(More)
Signal transduction of FMS-like tyrosine kinase 3 (FLT3) is regulated by protein-tyrosine phosphatases (PTPs). We recently identified the PTP DEP-1/CD148/PTPRJ as a novel negative regulator of FLT3. This study addressed the role of DEP-1 for regulation of the acute myeloid leukemia (AML)-related mutant FLT3 internal tandem duplication (ITD) protein. Our(More)
This paper begins by presenting AGENDA, a simulation tool developed for the simulation and design of applications involving interacting entities. This testbed consists of two different levels, the architecture level and the system-development level. The architecture level describes a methodology for designing software agents by providing several important(More)