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To gain wider acceptance for the use of agents in industry, it is a necessity to relate it to the nearest antecedent technology (object-oriented software development) and to introduce appropriate artifacts to support the development environment throughout the full system life cycle. We address both of these requirements by presenting agent UML, the Agent(More)
In the past, research on agent-oriented software engineering had been widely lacking touch with the world of industrial software development. Recently, a cooperation has been established between the Foundation of Intelligent Physical Agents (FIPA) and the Object Management Group (OMG) aiming to increase acceptance of agent technology in industry by relating(More)
In the past, research on agent-oriented software engineering had been widely lacking touch with the world of industrial software development. Recently, a cooperation has been established between the Foundation of Intelligent Physical Agents (FIPA) and the Object Management Group (OMG) aiming to increase acceptance of agent technology in industry by relating(More)
The use of layered architectures for modeling autonomous agents has become popular over the past few years. In this paper, different approaches how these architectures can be build are discussed. A special case, namely vertically layered architectures is discussed by the example of the INTERRAP agent model. The paper focusses on the lower levels of the(More)
The breakdown of the blood–brain barrier (BBB) is a key event in the development of sepsis-induced brain damage. BBB opening allows blood-born immune cells to enter the CNS to provoke a neuroinflammatory response. Abnormal expression and activation of matrix metalloproteinases (MMP) was shown to contribute to BBB opening. Using different mouse genotypes in(More)
Activity of the medial olivocochlear efferents can be inferred by measuring the change of the level of distortion product otoacoustic emissions (DPOAE) during ipsilateral or contralateral acoustic stimulation, the so-called medial olivocochlear reflex (MOCR). A limitation of this measurement strategy, however, is the distinct variability of MOCR values(More)