Jônatas Ferreira Lacerda

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C.B-17 scid/scid (severe combined immunodeficiency [SCID]) mice inoculated with peripheral blood lymphocytes from Epstein-Barr virus (EBV)-seropositive donors, or with EBV-transformed lymphoblastoid B cell lines (EBV-LCL), develop lethal human EBV+ B cell lymphoproliferative disorders (EBV-LPD) with characteristics similar to those arising in(More)
Epstein-Barr virus (EBV) is an ubiquitous herpesvirus which is carried as a latent infection of B lymphocytes and salivary gland epithelial cells in over 90% of normal adults. Latently infected EBV-transformed B cells circulate at low frequency in the blood for the life of the host. These transformed B cells stimulate a heterogeneous and complex host cell(More)
Impaired transport of methotrexate (MTX) is a common resistance mechanism of tumor cells to this drug. Trimetrexate (TMTX), a second-generation folate antagonist, is still active against MTX-transport-resistant cells because it enters cells by passive diffusion and does not use the reduced folate transport system for cell entry. Therefore, although(More)
Mice with severe combined immune deficiency (C.B-17 scid/scid [SCID mice]) lack functional B and T lymphocytes and are permissive for the growth of human xenografts. However, the development of functional NK cells is not affected by the scid mutation. Mouse NK cells express the surface glycolipid asialo GM1 and are implicated in the rejection of(More)
Recent studies have demonstrated that acute lymphoblastic leukemia-derived pre-B cell lines are deficient in their costimulatory function for T cell proliferation in response to the mitogen Con A and the superantigens TSST-1 and SEB. Stimulation of these pre-B cells with IL-7 increased their costimulatory function which involved the B7/CD28 pathway. In the(More)
A considerable portion of the cooling capacity losses on a household compressor occurs due to heating of the gas entering through the suction tube, which is called as superheating. A better understanding of the flow and heat transfer phenomena involved is crucial to improve compressor efficiency. In this work, it is presented a numerical simulation study(More)
Human Epstein-Barr virus-specific cytotoxic T lymphocytes (EBV-CTLs) prolong the survival of mice with severe combined immune deficiency bearing the autologous, but not HLA-mismatched, human EBV-induced lymphoproliferative disorders (EBV-LPDs). In the present study, we demonstrate that the HLA-restricted activity displayed by EBV-CTLs both in vitro and in(More)
How to deal with the heat exchange inside compressors is one of the main challenges on its design nowadays. The heating of the gas entering the compressors decreases its density reducing directly the mass flow and compressor efficiency, so should be avoid. To study this topic it was developed a full three-dimensional model of the gas and the solid parts(More)
Hermetic reciprocating compressors are widely used in small and medium size vapor compression refrigeration systems. One of the main parts of this type of compressor is the automatic valve system used to control the suction and discharge processes. As the opening and closing of the valves are caused by the forces produced by the refrigerant flow itself, the(More)