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Our studies clearly show that significantly longer remission duration was attained in groups of AML patients immunized with neuraminidase treated allogeneic myeloblasts as compared to patients who received chemotherapy alone or neuraminidase treated myeloblasts plus MER. IT is clear that MER, albeit apparently active alone in certain other clinical studies(More)
The data presented establish the therapeutic effectiveness of immunotherapy with neuraminidase-treated allogeneic myeloblasts in combination with sustaining chemotherapy in patients with acute myelocytic leukemia. The in vivo and in vitro immunologic tests indicate normal immunocompetence in patients receiving immunotherapy versus control patients treated(More)
The cancericidal efficacy of a new synthetic tripeptide was demonstrated using both in vitro cultures and in vivo tumorigenic assays. The antitumor agent PTT.119 (p-F-Phe-m-bis-(2-chloroethyl) amino-Phe-Met ethoxy HCl) was highly effective against three virulent murine tumor models; the L1210 leukemia, MJY-alpha mammary tumor and B16 melanoma. Treatment of(More)
To study the immunological effects of low-level occupational exposure to lead, we have examined the phenotypic parameters and functional integrity of peripheral blood lymphocytes in a group of firearms instructors and compared the data to those obtained from healthy unexposed controls. Our results indicate that, among individuals with mildly elevated blood(More)
SUMMARY The effects of D-glucosamine on the fine structures of Walker carcinoma and of the liver and kidney in rats were studied in vivo. Continuous administration of D-glucosamine for 18 hr resulted in a slight dilation of the cisternae of the endoplasmic reticulum and Golgi sacs of the tumor cells and liver parenchymal cells. The epithelial cells of the(More)