Jérôme Alexandre

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BACKGROUND CXCL12 has been widely reported to play a biologically relevant role in tumor growth and spread. In epithelial ovarian cancer (EOC), CXCL12 enhances tumor angiogenesis and contributes to the immunosuppressive network. However, its prognostic significance remains unclear. We thus compared CXCL12 status in healthy and malignant ovaries, to assess(More)
BACKGROUND The majority of patients receiving the platinum-based chemotherapy drug oxaliplatin develop peripheral neurotoxicity. Because this neurotoxicity involves ROS production, we investigated the efficacy of mangafodipir, a molecule that has antioxidant properties and is approved for use as an MRI contrast enhancer. METHODS The effects of(More)
BACKGROUND Infiltration by macrophages (Mphi) indicates a poor prognosis in breast cancers, in particular by inducing angiogenesis. Our study aimed 1) to investigate the mechanism by which cooperation between Mphi and aggressive breast cancer cells (MDA-MB-231) induces angiogenesis; 2) to examine the effect of tetrathiomolybdate (TM) on this angiogenic(More)
An increased number of regulatory T cells (Tregs) has been observed in the blood and tumor tissues of a high proportion of cancer patients, a phenomenon that promotes tumor progression and adversely affects prognosis. 1 Tregs express a series of markers including CD4, CD25 and the transcription factor FOXP3, which enables cells to suppress immune responses.(More)
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