Jérémy Lambert

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The multifunctional protein netrin-1 was initially discovered as the main attractive cue for commissural axon guidance by acting through its receptor DCC. Recently, we have shown that netrin-1 also interacts with the orphan transmembrane receptor amyloid precursor protein (APP). APP is cleaved by proteases, generating amyloid-β peptide, the main component(More)
BACKGROUND The Schizophrenia Caregiver Questionnaire (SCQ) was developed to assess the impact on caregivers of caring for patients with schizophrenia. The objective of this study was to develop a scoring algorithm for the SCQ, and evaluate its measurement properties. METHODS The SCQ was administered to 358 caregivers of patients with schizophrenia(More)
Background: The biological role of amyloid precursor protein (APP) during development is unknown. Results: We show that APP modulates netrin-1-mediated DCC-induced signaling. We also show the requirement for APP in netrin-1-mediated commissural axon outgrowth. Conclusion: APP is important for the netrin-1 role during neuronal navigation. Significance: In(More)
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