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BACKGROUND Pain is a frequent symptom during the course of multiple sclerosis (MS) but its frequency and impact at the early clinical stages remain unknown. OBJECTIVES The aim of this study was to establish prevalence and severity of pain in a cohort of patients recently diagnosed with MS and to determine the evolution of pain prevalence over 2 years.(More)
BACKGROUND Since indication extension to children data regarding the effectiveness of levetiracetam in paediatric patients remains limited. AIMS Investigate the real-life effectiveness of levetiracetam in paediatric patients. METHODS Epileptic children (<16 years) who had initiated levetiracetam between 1 October 2006 and 31 March 2007 were included and(More)
BACKGROUND AND OBJECTIVE To provide an overview of drug use in outpatient children in France, a population-based study using a national reimbursement claims database representative of 90% of the French population was conducted. DESIGN Cross-sectional study performed between January and December 2011 using the EGB database (Echantillon Généraliste de(More)
PURPOSE The effect of denominator options on event rates was tested on the French part of the Study of Acute Liver Transplant (SALT). METHODS SALT is a case population study of acute liver failure registered for transplantation (ALFT), exposed to non-steroidal anti-inflammatory drugs (NSAIDs) or non-overdose paracetamol, from 2005 to 2007. Population(More)
BACKGROUND Most NSAIDs are thought to be able to cause hepatic injury and acute liver failure (ALF), but the event rates of those leading to transplantation (ALFT) remain uncertain. OBJECTIVES The aim of the study was to estimate population event rates for NSAID-associated ALFT METHODS: This was a case-population study of ALFT in 57 eligible liver(More)
ETHNOPHARMACOLOGICAL RELEVANCE Trigonella foenum-graecum L. (TFG) is traditionally used to treat diabetes in North Africa. we therefore tested the effects of the hydro-alcoholic extract of TFG seeds in a C57/BL6J mouse model of diabetes induced by a standardised high-fat diet (HFD). MATERIALS AND METHODS Plant extracts (2 g/kg daily) were administered(More)
AIMS Acute drug overdose, especially with paracetamol, may cause acute liver failure leading to registration for transplantation (ALFT). Population statistics and between-country differences for ALFT related to overdose have been poorly described. The aim of the present study was to evaluate overdose ALFT in the multi-country Study of Acute Liver(More)
OBJECTIVES Effectiveness of bevacizumab for metastatic colorectal cancer in elderly patients has been investigated in observational studies, mainly associated with oxaliplatin-based regimens. Here, using the ETNA cohort in which the majority of patients received bevacizumab+FOLFIRI, the effectiveness of this combination in elderly patients is explored. (More)
PURPOSE Fear of discontinuing concomitant anti-epileptic drugs (AEDs) may lead to potentially unnecessary and perhaps unsafe polypharmacy. The effect of withdrawing concomitant AEDs on epilepsy control was therefore studied in long-term users of levetiracetam. METHODS The EULEV cohort followed patients initiating levetiracetam in France in 2005 or 2006(More)
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Levetiracetam has shown good safety/tolerability and efficacy in regulatory trials. This was confirmed in observational investigations performed soon after marketing by using continuation or retention rates as a composite measure. When an anti-epileptic drug first becomes available; however, there is evidence of(More)