Jérémy Jové

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BACKGROUND Pain is a frequent symptom during the course of multiple sclerosis (MS) but its frequency and impact at the early clinical stages remain unknown. OBJECTIVES The aim of this study was to establish prevalence and severity of pain in a cohort of patients recently diagnosed with MS and to determine the evolution of pain prevalence over 2 years.(More)
ETHNOPHARMACOLOGICAL RELEVANCE Trigonella foenum-graecum L. (TFG) is traditionally used to treat diabetes in North Africa. we therefore tested the effects of the hydro-alcoholic extract of TFG seeds in a C57/BL6J mouse model of diabetes induced by a standardised high-fat diet (HFD). MATERIALS AND METHODS Plant extracts (2 g/kg daily) were administered(More)
BACKGROUND Most NSAIDs are thought to be able to cause hepatic injury and acute liver failure (ALF), but the event rates of those leading to transplantation (ALFT) remain uncertain. OBJECTIVES The aim of the study was to estimate population event rates for NSAID-associated ALFT METHODS: This was a case-population study of ALFT in 57 eligible liver(More)
BACKGROUND AND OBJECTIVE To provide an overview of drug use in outpatient children in France, a population-based study using a national reimbursement claims database representative of 90% of the French population was conducted. DESIGN Cross-sectional study performed between January and December 2011 using the EGB database (Echantillon Généraliste de(More)
PURPOSE The effect of denominator options on event rates was tested on the French part of the Study of Acute Liver Transplant (SALT). METHODS SALT is a case population study of acute liver failure registered for transplantation (ALFT), exposed to non-steroidal anti-inflammatory drugs (NSAIDs) or non-overdose paracetamol, from 2005 to 2007. Population(More)
AIMS Acute drug overdose, especially with paracetamol, may cause acute liver failure leading to registration for transplantation (ALFT). Population statistics and between-country differences for ALFT related to overdose have been poorly described. The aim of the present study was to evaluate overdose ALFT in the multi-country Study of Acute Liver(More)
BACKGROUND Since indication extension to children data regarding the effectiveness of levetiracetam in paediatric patients remains limited. AIMS Investigate the real-life effectiveness of levetiracetam in paediatric patients. METHODS Epileptic children (<16 years) who had initiated levetiracetam between 1 October 2006 and 31 March 2007 were included and(More)
BACKGROUND Several methods have been proposed to assess causality in drug-induced liver injury but none have been tested in the specific context of acute liver failure leading to transplantation (ALFT). OBJECTIVE We took advantage of the Study of Acute Liver Transplant (SALT), a European case-population study of ALFT, to test different causality scales.(More)
OBJECTIVES Effectiveness of bevacizumab for metastatic colorectal cancer in elderly patients has been investigated in observational studies, mainly associated with oxaliplatin-based regimens. Here, using the ETNA cohort in which the majority of patients received bevacizumab+FOLFIRI, the effectiveness of this combination in elderly patients is explored. (More)
© 2013 Lippincott Williams & Wilkins www.epidem.com | 935 The case-population ratio is perpendicular to the RR: rather than the ratio of case rates among exposed and unexposed, it is the ratio of exposure rates among cases and population. In the usual two-by-two table (Table), where a is the number of exposed cases, b the number of exposed noncases, c the(More)