János Roszik

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Adoptive transfer of T cells that are gene engineered to express a defined TCR represents a feasible and promising therapy for patients with tumors. However, TCR gene therapy is hindered by the transient presence and effectiveness of transferred T cells, which are anticipated to be improved by adequate T cell costimulation. In this article, we report the(More)
The acceptor photobleaching fluorescence resonance energy transfer (FRET) method is widely used for monitoring molecular interactions in cells. This method of FRET, while among those with the simplest mathematics, is robust, self-controlled and independent of fluorophore amounts and ratios. AccPbFRET is a user-friendly, efficient ImageJ plugin which allows(More)
The intensity-based ratiometric FRET (fluorescence resonance energy transfer) method is a powerful technique for following molecular interactions in living cells. Since it is not based on irreversibly destroying the donor or the acceptor fluorophores, the time course of changes in FRET efficiency values can be monitored by this method. ImageJ, a(More)
This paper deals with a retrial queueing system with a finite number of homogeneous sources of calls and a single non-reliable server, which means that the server is subject to random breakdowns depending on whether it is busy or idle. The failure of the server may block or unblock the systems’s operations and the service of the interrupted request may be(More)
Elisidepsin is a marine-derived anti-tumor agent with unique mechanism of action. It has been suggested to induce necrosis associated with severe membrane damage. Since indirect evidence points to the involvement of ErbB receptor tyrosine kinases and lipid rafts in the mechanism of action of elisidepsin, we investigated the effect of the drug on the(More)
We aimed to study the histological and cytological alterations induced by cylindrospermopsin (CYN), a protein synthesis inhibitory cyanotoxin in roots of common reed (Phragmites australis). Reed is an ecologically important emergent aquatic macrophyte, a model for studying cyanotoxin effects. We analyzed the histology and cytology of reed roots originated(More)
T-cell receptors (TCRs) can be genetically modified to improve gene-engineered T-cell responses, a strategy considered critical for the success of clinical TCR gene therapy to treat cancers. TCR:ζ, which is a heterodimer of TCRα and β chains each coupled to complete human CD3ζ, overcomes issues of mis-pairing with endogenous TCR chains, shows high surface(More)
This paper is concerned with the performance analysis of finite-source retrial queues with heterogeneous sources operating in random environments. All random variables involved in the model construction are assumed to be exponentially distributed with a parameter depending on the source index and on the state of the corresponding random environment. The(More)
BACKGROUND AND AIMS Microcystin-LR (MCY-LR) is a cyanobacterial toxin, a specific inhibitor of type 1 and 2A protein phosphatases (PP1 and PP2A) with significant impact on aquatic ecosystems. It has the potential to alter regulation of the plant cell cycle. The aim of this study was improved understanding of the mitotic alterations induced by cyanotoxin in(More)
In wireless multihop networks each node acts as a relay for the other nodes. Consequently, the distribution of the traffic load has a strong spatial dependence. We consider a dense multihop network where the routes are approximately straight line segments. To this end we introduce the so-called line segment traversing process which defines the movement of(More)