János Podani

Learn More
A central and long-standing issue in evolutionary theory is the origin of the biological variation upon which natural selection acts. Some hypotheses suggest that evolutionary change represents an adaptation to the surrounding environment within the constraints of an organism's innate characteristics. Elucidation of the origin and evolutionary relationship(More)
The use of mathematical methods based on Shannon's entropy function is proposed for the evaluation of the consequences of sampling unit size and for the study of vegetation succession. The concept of diversity is extended to sets of phytosociological relevés under the term florula diversity. It is shown that Shannon's entropy as well as two other related(More)
In this paper we emphasize that sampling decisions in population and community ecology are context dependent. Thus, the selection of an appropriate sampling procedure should follow directly from considerations of the objectives of an investigation. We recognize eight sampling alternatives, which arise as a result of three basic dichotomies: parameter(More)
OBJECTIVE Tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, has recently been approved as a biological therapy for rheumatoid arthritis (RA) and other diseases. It is not known if there are characteristic changes in gene expression and immunoglobulin G glycosylation during therapy or in response to treatment. METHODS Global gene(More)
Although several studies have examined the functional diversity of freshwater macroinvertebrates, the variety of methodologies combined with the absence of a synthetic review make our understanding of this field incomplete. Therefore, we reviewed the current methodology for assessing functional diversity in freshwater macroinvertebrate research. Our review(More)
Functional diversity is regarded as a key in understanding the link between ecosystem function and biodiversity, but its measurement is rather problematic. The two widely used continuous measures are the dendrogram-based measure (DBM) and the functional attribute diversity (FAD). In contrast to DBM, FAD does not require the knowledge of the entire species(More)
Biological therapies have been introduced for the treatment of chronic inflammatory diseases including rheumatoid arthritis (RA) and Crohn's disease (CD). The efficacy of biologics differs from patient to patient. Moreover these therapies are rather expensive, therefore treatment of primary non-responders should be avoided. We addressed this issue by(More)
Fibrous dysplasia is an isolated skeletal disorder caused by a somatic activating mutation of GNAS gene with abnormal unmineralized matrix overproduction and extensive undifferentiated bone cell accumulation in the fibro-osseous lesions. The aim of our investigation was to identify genes that are differently expressed in fibrous versus non-fibrous human(More)