János Mészáros

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Cardiac hypertrophy was induced in rats by daily injection of isoproterenol (5 mg/kg ip) for 7 days. Membrane voltage and currents were recorded using the whole cell patch-clamp technique in left ventricular myocytes from control and hypertrophied hearts. Ryanodine-sensitive delayed afterdepolarizations (DADs) and transient inward current (I(ti)) appeared(More)
The lesions of medial habenular nuclei increased the pain sensitivity, enhanced the analgesic activity of morphine and slightly activated the behavior. The lesion of fasciculus retroflexus, a pathway connecting habenular nuclei with interpeduncular nucleus enhanced the pain sensitivity less markedly, did not change the efficacy of morphine analgesia, but(More)
In the early (3-day) stage of development, long-lasting openings of the L-type Ca2+ channels (mode 2) occur in embryonic chick heart cells. Since mode-2 behavior is infrequently observed in adult heart cells of other species, in the present study, developmental change in behavior of the Ca2+ channel was examined in young (3-day) and old (17-day) embryonic(More)
BACKGROUND Two pertussis toxin sensitive G(i) proteins, G(i2) and G(i3), are expressed in cardiomyocytes and upregulated in heart failure. It has been proposed that the highly homologous G(i) isoforms are functionally distinct. To test for isoform-specific functions of G(i) proteins, we examined their role in the regulation of cardiac L-type(More)
AIMS Cardiac L-type Ca(2+)-currents show distinct alterations in chronic heart failure, including increased single-channel activity and blunted adrenergic stimulation, but minor changes of whole-cell currents. Expression of L-type Ca(2+)-channel beta(2)-subunits is enhanced in human failing hearts. In order to determine whether prolonged alteration of(More)
The aim of our four-year longitudinal survey was to compare the somatic and motor development of 7-year-old girls growing up in families that need continuous municipal financial support, respectively to the ones not needing it. Eight consecutive data collections were carried out in three geographic and economic regions of Hungary from 2003 to 2007. The(More)
This exploratory investigation examined the association between maximal aerobic power (VO2max) and blood pressure (BP) and heart rate (HR) reactivity to mental challenge. Adolescent male judo athletes (n = 20) performed a 2-min mental arithmetic. Heart rate was recorded before, during, and after the arithmetic, and BP was recorded before and after the(More)
The aim of the present comparison of Roma and non-Roma prepubertal boys was to analyse if there were differences in some anthropometric measures and in running performance to see if Roma children fall behind their non-Roma peers in growth and development, and if so, to what extent. Until now no larger child sample of exclusively Roma ethnicity has been(More)
Rats were injected into one lateral ventricle (icv) with apamin (50 and 100 ng per animal). The resulting desynchronization pattern in the electro-corticogram (ECoG) and the symptoms of apaminism (uncoordinated hypermotility and jerks) were monitored. The results of presented experiments contributed additional data concerning the topography of apamin(More)
Introduction With the onset of atrial fibrillation (AF), atrial activation rates increase 5-to 7-fold (1). Initially, this causes intracellular Ca 2+ overload (2). Subsequent adaptation to the high rate (atrial remod-eling) leads to a " self-correction, " with the transient high intra-cellular Ca 2+ returning to near-normal levels (3). However, while(More)