Iwona Nowak

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The clinical severity of Osteogenesis Imperfecta (OI), also known as the brittle bone disease, relates to the extent of conformational changes in the collagen triple helix induced by Gly substitution mutations. The lingering question is why Gly substitutions at different locations of collagen cause different disruptions of the triple helix. Here, we(More)
The recently discovered MCPIP1 (monocyte chemoattractant protein-induced protein 1), a multidomain protein encoded by the MCPIP1 (ZC3H12A) gene, has been described as a new differentiation factor, a ribonuclease, and a deubiquitination-supporting factor. However, its role in cancer is poorly recognized. Our recent analysis of microarrays data showed a lack(More)
The main physiological function of MCPIP1 (regnase-1) is negative regulation of inflammation. Moreover, roles of regnase-1 in apoptosis and differentiation have also been described, but its involvement in cancer is yet to be fully recognized. Earlier, we showed a lack of expression of MCPIP1 in both primary tumors and several neuroblastoma cell lines.(More)
BACKGROUND Patients with inflammatory bowel disease (IBD) who are treated long-term with immunosuppressive drugs can experience a decrease in their overall resistance to infections, including influenza. The purpose of this study was to evaluate the humoral response in children with IBD after being vaccinated against influenza. MATERIAL/METHODS Children(More)
Since 1997, human infections with highly pathogenic zoonotic avian influenza viruses have shown that the risk of influenza pandemic is significant. In Europe, infections caused by the highly pathogenic avian influenza A(H7N7) virus were confirmed in the human population in 2003 in the Netherlands. Moreover, outbreaks of A(H5N1) infections were observed in(More)
A total number of 251,815 cases of influenza and influenza-like illness registered in Poland in 2006 (incidence 660.4 per 100,000 population). Regionally the incidence varied from 75.6 per 100,000 in swietokrzyskie voivodeship to 1,690.4 in mazowieckie. The highest reported incidence was observed in age group 0-4 years (1,543.1 per 100,000). Children and(More)
A total number of 227,346 cases of influenza and influenza-like illness were registered in Poland in 2008 (incidence 596.5 per 100,000 population). Compared to 2007 on 39.2% incidence decrease was observed. Regionally the incidence varied from 142.3 in swietokrzyskie voivodeship to 1,830.6 in opolskie. Children and adolescents under 15 years of age(More)
The continuous casting process of metals and alloys is nowadays frequently utilized in metallurgical industry, and more general in material engineering. Typically, the liquid material flows into the mould (crystallizer) having the walls cooled by flowing water. The solidifying ingot is pulled out by the withdrawal rolls. Below the mould the side surface of(More)
A paper illustrates the use of two metaheuristics: Genetic Algorithm and Ant Colony Optimization in darts play. The goal of the game is to hit on the centre of the dartboard. Both the creation of physical model and the optimization of the problem (based on heuristic algorithms) are presented in details. Two approaches are discussed and compared with respect(More)