Filter Results:
- Full text PDF available (10)
Publication Year
1999
2018
- This year (4)
- Last 5 years (15)
- Last 10 years (74)
Publication Type
Co-author
Journals and Conferences
Learn More
- Rob Leurs, Paul Louis Chazot, Fiona C. Shenton, Herman D. Lim, Iwan J.P. de Esch
- British journal of pharmacology
- 2009
The elucidation of the human genome has had a major impact on histamine receptor research. The identification of the human H4 receptor by several groups has been instrumental for a new appreciation… (More)
- Radovan Spurny, Joachim Ramerstorfer, +13 authors Chris Ulens
- Proceedings of the National Academy of Sciences…
- 2012
GABA(A) receptors are pentameric ligand-gated ion channels involved in fast inhibitory neurotransmission and are allosterically modulated by the anxiolytic, anticonvulsant, and sedative-hypnotic… (More)
- Dennis Verzijl, Stefania Storelli, +10 authors Rob Leurs
- The Journal of pharmacology and experimental…
- 2008
The chemokine receptor CXCR3 is involved in various inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, psoriasis, and allograft rejection in transplantation patients. The CXCR3… (More)
- Herman D. Lim, Rogier A. Smits, Remko A. Bakker, Cindy M E van Dam, Iwan J.P. de Esch, Rob Leurs
- Journal of medicinal chemistry
- 2006
During an in-house database screen, we identified S-(2-guanidylethyl)-isothiourea as a high affinity agonist for the histamine H4 receptor, with a 33-fold selectivity over the histamine H3 receptor… (More)
- Oscar P J van Linden, Albert J. Kooistra, Rob Leurs, Iwan J.P. de Esch, Chris de Graaf
- Journal of medicinal chemistry
- 2014
Protein kinases regulate the majority of signal transduction pathways in cells and have become important targets for the development of designer drugs. We present a systematic analysis of… (More)
- Rob Leurs, Henry F. Vischer, Maikel Wijtmans, Iwan J.P. de Esch
- Trends in pharmacological sciences
- 2011
With the recognition of two new histamine receptors at the start of the new millennium, the field of histamine research has seen a clear revival. In the last 10 years, many academic and industrial… (More)
- Janneke W. Hulshof, Paola Casarosa, +5 authors Rob Leurs
- Journal of medicinal chemistry
- 2005
US28 is a human cytomegalovirus (HCMV) encoded G-protein-coupled receptor that signals in a constitutively active manner. Recently, we identified 1… (More)
- Iwan J.P. de Esch, Robin L. Thurmond, Aldo Jongejan, Rob Leurs
- Trends in pharmacological sciences
- 2005
Following the sequencing of the human genome, data-mining efforts have revealed the existence of a new histamine receptor that is expressed at high levels in mast cells and leukocytes. The histamine… (More)
- Sylvain Célanire, Maikel Wijtmans, Patrice E Talaga, Rob Leurs, Iwan J.P. de Esch
- Drug discovery today
- 2005
Antagonists of the histamine H(1) and H(2) receptors have been successful as blockbuster drugs for treating allergic conditions and gastric ulcers, respectively. As such, histamine receptors have… (More)
- Rogier A. Smits, Iwan J.P. de Esch, +7 authors Rob Leurs
- Journal of medicinal chemistry
- 2008
From a series of small fragments that was designed to probe the histamine H(4) receptor (H(4)R), we previously described quinoxaline-containing fragments that were grown into high affinity H(4)R… (More)