Ivna Svoboda-Beusan

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AIM To determine whether local antibiotic resistance involves P-glycoprotein (Pgp)-mediated active drug out-pumping during Helicobacter pylori (H pylori) infection treatment with classic antibiotic therapy. METHODS Pgp activity was determined in gastric mucosa biopsy specimens obtained from 53 patients with pathohistologically verified gastritis and(More)
BACKGROUND AND OBJECTIVES The aim of this study was to determine whether expression of P-glycoprotein (Pgp) is an intrinsic feature of B-lymphocytes in B-cell chronic lymphocytic leukemia (B-CLL) and how it correlates with hematologic indices and tumor load in the disease. Furthermore, the change of Pgp expression under cytotoxic treatment and its(More)
OBJECTIVE To assess immune reactivity in men just released from a war prisoner camp. PARTICIPANTS Random sample of 29 men from a group of 764 liberated detainees in war prisoner camp in Bosnia, 15 matched healthy control subjects, and pre-war historical control subjects. MAIN OUTCOME MEASURES Report on immune reactivity parameters, such as lymphocyte(More)
P-glycoprotein is important in local antibiotic resistance. Aim was to evaluate the role of P-glycoprotein in local antibiotic resistance in patients with antral gastritis during antibiotic therapy to Helicobacter pylori infection. In the group of 53 patients with pathohistologically verified gastritis and microbiologically confirmed H. pylori infection (no(More)
PMA (10, 20 ng/ml) and doxorubicin (5-20 ng/ml) decreased the viability and MTT-activity of NALM-1 pre-B leukemic cells (3 days' treatment). Further, CD10 was downregulated, suggesting that PMA and doxorubicin induced differentiation of NALM-1 cells. However, PMA did not alter expression of B cell markers CD20 and of mIgM. In contrast to PMA, another(More)
Percentage counts of T-lymphocytes (helper and suppressor subpopulation) and B-lymphocytes were performed in the peripheral blood of two confirmed cases of HFRS infection using Coulter Clone monoclonal antibodies and Becton Dickinson flow cytometry. The individual values were compared with those from healthy subjects. HFRS patients had lower total T-cell(More)
In an attempt to standardize the normal values for immunological tests it is necessary to establish strict admission criteria. The EURAGE Concerted Action Programme on Ageing of the European Community described the SENIEUR protocol with criteria for immunological studies in man, based on clinical and laboratory information. Our results on humoral and(More)
The peripheral blood lymphocyte phenotypes of 20 healthy young normal subjects between the ages 21 and 29 were determined by dual fluorescence analysis with fluorochrome--labeled monoclonal antibodies (mAbs). Samples were prepared by a whole blood lysis technique and analysed on a FACScan flow cytometer using SimulSET Software. Values for lymphocyte(More)
Using monoclonal antibodies authors determined the percentage of CD2(+)-, CD4(+)- and CD8(+)-lymphocytes in the peripheral blood of 45 asthmatic children. In 38 subjects asthma was reaginic, while in 7 it was nonreaginic. The aim of the study was to detect an abnormality which might contribute to the pathogenesis of the disease. A correlation test was done(More)
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