Iveta Nováková

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BACKGROUND The aim of this study was to evaluate the clinical value of markers of bone remodeling in assessment of rate of bone loss in patients with multiple sclerosis (MS) long term treated with low dose glucocorticoids. METHODS The study involved 70 patients with MS. Motor function of the patients was evaluated using the Kurtzke Expanded Disability(More)
Objective: When Sativex  THC:CBD cannabinoid-based oromucosal spray was first approved as a prescription medicine for multiple sclerosis (MS) spasticity, there was some concern about its possible long-term impact on cognition and mood. The objective of this study was therefore to assess the long-term impact of Sativex on cognitive function and mood in MS(More)
In an immunological survey of the population it was revealed that the population above 60 years is not adequately protected against tetanus. This is probably to a considerable extent due to changes in the immune system as a result of age-conditioned changes and also due to an inadequate stimulus in the form of vaccine. The author prepared therefore an(More)
The aim of this work was to conduct a comprehensive study about the transport properties of NSAIDs across the blood-brain barrier (BBB) in vitro. Transport studies with celecoxib, diclofenac, ibuprofen, meloxicam, piroxicam and tenoxicam were accomplished across Transwell models based on cell line PBMEC/C1-2, ECV304 or primary rat brain endothelial cells.(More)
This paper is concerning the issues of behaviour of lightweight expanded clay aggregates concrete exposed to high temperature. Lightweight aggregates from expanded clay are produced by firing of row material up to temperature 1050°C. Lightweight aggregates have suitable properties in terms of volume stability, when exposed to temperatures up to 1050°C,(More)
BACKGROUND Myasthenia gravis (MG) is the autoimmune disorder in which the thymus is considered the pathogenic organ. Thymectomy (TE) is a therapeutic option for MG and often ameliorates clinical symptoms. METHODS We evaluated clinical features and outcomes after TE in patients without thymoma and the influence of TE with or without concomitant(More)
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