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The tobacco plant contains nickel and several other toxic metals, most probably absorbed from the soil, fertilizing products or from pesticides. It has been stated that nickel in a burning cigarette might form the volatile, gaseous compound, nickel tetracarbonyl, and thereby be introduced into the respiratory tract. Accordingly, the main objective of the(More)
Metoclopramide is a drug which has experienced worldwide use in the clinic for over 30 years as an antiemetic. Recently, it has also been shown to possess radio- and chemosensitizing properties in both animal tumour models and humans at the higher dose of 2 mg/kg. Two new metoclopramide formulations are being clinically developed and they differ mainly in(More)
One of the basic problems in monitoring exposure of nickel refining workers has been the unclear correlation between plasma nickel, urine nickel, and airborne nickel during the eight-hour work period or throughout the 24-hour day. In previous studies the authors have demonstrated the value of biological sampling in an occupational health program in the(More)
Earlier work-related lung and nasal cancer studies included estimates of exposures to different nickel species in the refinery. Based on the metallurgy, only insoluble nickel was believed to be present around the roasters but mixed exposure was assumed in most areas, including the tankhouse. Occasional leaching tests of samples from the roaster area have(More)
Lung specimens from 39 nickel refinery workers autopsied during the period from 1978 to 1984 were analyzed for nickel. Fifteen of the workers were employed in the Roasting and Smelting Department, where exposure to nickel was predominantly in the form of nickel-copper oxides, Ni3S2 and metallic dust. The remaining 24 men worked in the Electrolysis(More)
The objective of the present investigation was to study the influence of the occupational nickel exposure on the concentration of nickel in nasal mucosa, plasma and urine. Plasma, urine and biopsy specimens of nasal mucosa from 318 nickel workers, 15 retired nickel workers and 57 non-exposed controls were analyzed for nickel by atomic absorption(More)
Biopsy specimens from nasal mucosa of 30 nickel-exposed individuals and 6 controls were analysed by atomic absorption spectrophotometry to determine the content of nickel, copper, cobalt, zinc and iron. Timm's sulphide silver staining method was used for visualizing heavy metals in cryostat sections of biopsy material from each individual. The purpose of(More)
OBJECTIVE The purpose of this work was to study the distribution of nickel within lung tissue obtained from nickel-exposed people and to evaluate the use of only one single sample for determination of the nickel burden of the lung. METHODS AND MATERIALS The material used was lung tissue obtained from 15 former nickel refinery workers who had been exposed(More)
Histochemical methods and energy dispersive X-ray micro-analysis (EDX-analysis) were evaluated in model experiments and on tissue sections for their usefulness in detecting traces of metals in biological tissue. The goal for this study was to establish a method for localization of nickel deposits in the nasal mucosa, where it has been found in(More)
People working in the nickel refining industry are known to have a higher concentration of nickel in lung tissue than the general population. To be able to evaluate a potential nickel exposure from other sources, e.g., welding, it is important to have sufficient data on what is normal for a local population. Several local factors such as the content of(More)