Ivana Stankova

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In recent years metabotropic glutamate receptors (mGluRs) have received considerable attention as a potential target for psychotropic drugs, but their influence on learning and memory is still unclear. The aim of the present study was to examine whether intraperitoneal (i.p.) administration of selective mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyrydine(More)
Immunostimulatory properties of B. firmus, a nontoxic, nonpathogenic G + bacterium of external environment, were described previously. Antiinfectious and antitumor activity, macrophage activation and strong polyclonal stimulation of B lymphocytes were proved in human, mice and rats. The adjuvant effect of B. firmus on specific antibody response to ovalbumin(More)
Testing of cytokine levels in colostrum, cord blood and amniotic fluid of healthy and allergic mothers and their newborns (using protein microarrays and quantitative analysis by ELISA) revealed differences in the levels of IL-5, IL-10, TGF-β, TNF-α, EGF and eotaxin between healthy and allergic groups. Significantly higher concentration of IL-5 and IL-10 in(More)
Bacillus firmus (a Gram-positive nonpathogenic and harmless bacterium), was shown to be a strong polyclonal activator of mouse B lymphocytes as estimated by ELISA testing of Ig concentrations in culture supernatants after incubation of BALB/c mouse splenocytes with inactivated bacillus. Synthesis of all main Ig classes and all IgG subclasses was(More)
AIMS The differential diagnosis of thyroid nodules in routine practice can be problemmatic for both pathologists and clinicians. Effective treatment requires a determination of the biological nature of the lesions. For this reason, ancilliary diagnostic markers along with histological examination of the nodules may be useful. The objective of this study was(More)
Using a modification of the ELISA method, auto-antibodies against the own nervous tissue have been identified in the serum of laboratory rats. The prevalence of the IgM class of antibodies suggests their physiological significance. Antibody levels are higher in females than in males. Brain hypoxic injury brings about a shift in the spectrum of antibodies(More)
An interference between a thermosensitive (ts) mutant and the wild-type (wt) of tick-borne encephalitis (TBE) virus in Ixodes ricinus L. and Rhipicephalus appendiculatus (Neumann) ticks is reported. I. ricinus females were dually infected by a parenteral inoculation of ts and wt strains at 10-day interval. Interference was demonstrated by the lowered(More)
A decrease of external pH during rhythmic excitation of the nerve of frog and squid was investigated. The level of pH was dependent on frequency excitation, concentration of sodium potassium and hydrogen ions was changed after ouabain, 2,4-dinitrophenol, tetraethylammonium and tetrodotoxin effect. The mechanism of proton transport was discussed in relation(More)