Ivana P. Janković

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Genome-wide association (GWA) studies have identified a large number of SNPs associated with disease phenotypes. As most GWA studies have been performed in populations of European descent, this Review examines the issues involved in extending the consideration of GWA studies to diverse worldwide populations. Although challenges exist with issues such as(More)
IVANA JANKOVIC,* BRIDGETT M. V O N HOLDT† and NOAH A. ROSENBERG*‡ *Center for Computational Medicine and Bioinformatics, University of Michigan, 2017 Palmer Commons, 100 Washtenaw Ave., Ann Arbor, MI 48109, USA, †University of California, Los Angeles, Ecology & Evolutionary Biology, 621 Charles E. Young Dr. South, Los Angeles, CA 90095, USA, ‡Department of(More)
Gene diversity, a commonly used measure of genetic variation, evaluates the proportion of heterozygous individuals expected at a locus in a population, under the assumption of Hardy-Weinberg equilibrium. When using the standard estimator of gene diversity, the inclusion of related or inbred individuals in a sample produces a downward bias. Here, we extend a(More)
With the recent rapid advances in medical technology there are a variety of intrusive procedures used in the medical industry today requiring tools, instruments, sensors and components in materials that are inert with respect to reactions with the body. More, new surgical techniques have been developed to improve the quality of operations, reduce the risk(More)
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