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BORIS is a paralog of a highly conserved, multi-functional chromatin factor CTCF. Unlike CTCF, which has been shown to possess tumor-suppressive properties, BORIS belongs to the “cancer/testis antigen” family normally expressed only in germ cells and aberrantly activated in a variety of tumors. The consequences of BORIS expression, relative abundance of its(More)
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (FAU) gene is down-regulated in human prostate, breast and ovarian cancers. Moreover, its dysregulation is associated with poor prognosis in breast cancer. Sponges (Porifera) are animals without tissues which branched off first from the common ancestor of all metazoans. A large(More)
Glucocorticoids and their receptor (GR) have been an important area of research because of their pleiotropic physiological functions and extensive use in the clinic. In addition, the association between GR and glucocorticoids, which is highly specific, leads to rapid nuclear translocation where GR associates with chromatin to regulate gene transcription.(More)
Mass spectrometry (MS) are a group of a high-throughput techniques used to increase knowledge about biomolecules. They produce a large amount of data which is presented as a list of hundreds or thousands of proteins. Filtering those data efficiently is the first step for extracting biologically relevant information. The filtering may increase interest by(More)
Liver is a unique mammalian organ with a great capacity of regeneration related to its function. After surgical resection or injury, hepatic cells, especially hepatocytes, can proliferate rapidly to repair the damage and to regenerate the structure without affecting the function of the liver. Loss of catalase activity during regeneration indicates that(More)
With recent technological developments, modern computing systems are becoming more and more powerful. Common computers are capable of calculating more than 50,000 million instructions per second. Currently the biggest obstacle in computer usage is slow communication between the human and the computer. With innovation and development of novel (natural based)(More)
BACKGROUND Sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) are NAD+-dependent protein deacetylases involved in the regulation of key cancer-associated genes. In this study we evaluated the relevance of these deacetylases in lung cancer biology. MATERIAL AND METHODS Protein levels of SIRT1 and SIRT2 were determined in non-small cell lung cancer (NSCLC) cell lines(More)
EpigeneƟ cs is focused on gene physiology, analyzing inherited variaƟ ons in gene expression, while genomics is focused on gene anatomy, analyzing gene structure. DNA methylaƟ on and histone post-translaƟ onal modifi caƟ ons are the basic epigeneƟ c mechanisms regulaƟ ng gene acƟ vity. These two processes complement each other, creaƟ ng an epigeneƟ c(More)
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