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1 Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA 2 Department of Oral Biology, University of Washington School of Dentistry, Seattle, WA, USA 3 Department of Medicinal Chemistry, University of Washington School of Pharmacy, Seattle, WA, USA 4 Department of Medicine (Dermatology), University of Washington School of(More)
Phosphorylation of tau protein is a critical event in the pathogenesis of Alzheimer's disease (AD). Increased phosphorylated tau and total tau levels, combined with reduced concentrations of amyloid-β 1-42 (Aβ42) in cerebrospinal fluid (CSF), but not in plasma or serum, have been generally accepted as sensitive AD diagnostic markers. However, obtaining CSF(More)
Chronic graft-versus-host disease (cGVHD) is an immune-mediated disorder and is the major long-term complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). The oral mucosa, including the salivary glands, is affected in the majority of patients with cGVHD; however, at present there is only a limited understanding of disease(More)
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