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CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib.
Modulating protein ubiquitination via proteasome inhibition represents a promising target for cancer therapy, because of the higher sensitivity of cancer cells to the cytotoxic effects of proteasome… Expand
Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer.
- Bruce D. Dorsey, M. Iqbal, +15 authors J. Mallamo
- Chemistry, Medicine
- Journal of medicinal chemistry
- 5 February 2008
The ubiquitin-proteasome pathway plays a central role in regulation of the production and destruction of cellular proteins. These pathways mediate proliferation and cell survival, particularly in… Expand
High-performance liquid chromatography-electrospray ionization mass spectrometry and multiple mass spectrometry studies of hyperforin degradation products.
- N. Fuzzati, B. Gabetta, I. Strepponi, F. Villa
- Chemistry, Medicine
- Journal of chromatography. A
- 10 August 2001
The alcoholic extract of the aerial parts of Hypericum perforatum L. finds wide application because of its antidepressant activity. The extract contains a number of constituents with documented… Expand
Phase I/II Trial of Sorafenib in Combination with Vinorelbine as First-Line Chemotherapy for Metastatic Breast Cancer
Background Preclinical models have reported a synergistic interaction between sorafenib and vinorelbine. We investigated the toxicity, efficacy, and pharmacokinetics interaction of this combination… Expand
Biodistribution of paclitaxel poliglumex (PPX) in lung: Analysis of gender-related alterations in a preclinical model.
- C. Allievi, I. Strepponi, +7 authors J. Singer
- Journal of clinical oncology : official journal…
- 20 June 2006
17003 Background: PPX is a macromolecular drug conjugate that links paclitaxel with poly-L-glutamic acid; the release of paclitaxel is dependent on metabolism by lysosomal proteases, particularly… Expand
Heparin in vitro permeation study through human skin
- H. C. Sacco, I. Strepponi, Antonella Casiraghi, S. Franzé, M. Pinza, P. Minghetti
- 1 June 2011