Ivan Pelivanov

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The advantages of photoacoustic (PA) imaging, including low cost, non-ionizing operation, and sub-mm spatial resolution at centimeters depth, make it a promising modality to probe nanoparticle-targeted abnormalities in real time at cellular and molecular levels. However, detecting rare cell types in a heterogeneous background with strong optical scattering(More)
Because of depth-dependent light attenuation, bulky, low-repetition-rate lasers are usually used in most photoacoustic (PA) systems to provide sufficient pulse energies to image at depth within the body. However, integrating these lasers with real-time clinical ultrasound (US) scanners has been problematic because of their size and cost. In this paper, an(More)
Optoacoustic (OA) imaging utilizes short laser pulses to create acoustic sources in tissue and time resolved detection of generated pressure profiles for image reconstruction. The ultrasonic transients provide information on the distribution of optical absorption coefficient that can be useful for early cancer diagnostics. In this work a new design of(More)
Ultrasonic NDE is one of the most promising methods for non-destructive diagnostics of residual stresses. However the relative change of sound velocity, which is directly proportional to applied stress, is extremely small. An initial stress of 100 MPa produces the result of deltaV/V approximately 10(-4). Therefore measurements must be performed with high(More)
The calibration dependencies of the optoacoustic (OA) transformation efficiency on tissue temperature are obtained for the application in OA temperature monitoring during thermal therapies. Accurate measurement of the OA signal amplitude versus temperature is performed in different ex vivo tissues in the temperature range 25°C to 80°C. The investigated(More)
Contrast-enhanced photoacoustic (PA) imaging has been proposed to identify circulating metastatic cancer cells magnetically trapped in the vasculature. However, its sensitivity is limited by the presence of a strong blood-background signal. This technique can be further improved by the significant suppression of blood background. In the phantom study(More)
One of the major medical applications of optoacoustic (OA) tomography is in the diagnostics of early-stage breast cancer. A numerical approach was developed to characterize the following parameters of an OA imaging system: resolution, maximum depth at which the tumor can be detected, and image contrast. The parameters of the 64-element focused array(More)
Photoacoustic (PA) imaging has been demonstrated to be a promising modality in molecular imaging for detection of nanoparticle-targeted diseased cells or tissues. However, intrinsic absorbers, such as blood, produce strong PA background signals that severely degrade the detection sensitivity and specificity of targeted objects. Magnetomotive photoacoustic(More)
Results on magnetically trapping and manipulating micro-scale beads circulating in a flow field mimicking metastatic cancer cells in human peripheral vessels are presented. Composite contrast agents combining magneto-sensitive nanospheres and highly optical absorptive gold nanorods were conjugated to micro-scale polystyrene beads. To efficiently trap the(More)