Ivan Novak

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INTRODUCTION Our understanding of septic acute kidney injury (AKI) remains incomplete. A fundamental step is the use of animal models designed to meet the criteria of human sepsis. Therefore, we dynamically assessed renal haemodynamic, microvascular and metabolic responses to, and ultrastructural sequelae of, sepsis in a porcine model of faecal(More)
INTRODUCTION In almost half of all sepsis patients, acute kidney injury (AKI) develops. However, the pathobiologic differences between sepsis patients with and without AKI are only poorly understood. We used a unique opportunity to examine dynamic inflammatory, renal hemodynamic, and microvascular changes in two clinically relevant large-animal models of(More)
In recent two years, a global spread of NDM-type metallo-beta-lactamase-producing bacteria has been observed. NDM enzymes are mainly produced by Enterobacteriaceae, but have also been detected in Acinetobacter baumannii and Vibrio spp. as well (Tzouvelekis et al. 2012; Walsh et al. 2011). Two cases of the new variant, NDM-4, have been recently described in(More)
INTRODUCTION It is recognized that administration of insulin with glucose decreases catabolic response in sepsis. The aim of the present study was to compare the effects of two levels of insulinaemia on glucose metabolism and energy expenditure in septic patients and volunteers. METHODS Glucose uptake, oxidation and storage, and energy expenditure were(More)
OBJECTIVE To evaluate the effects of prone position on hepato-splanchnic hemodynamics, metabolism and gut mucosal energy balance. DESIGN Prospective clinical study. SETTING Medical intensive care unit in a university hospital. PATIENTS Eleven hemodynamically stable patients with acute lung injury (ALI) requiring mechanical ventilation. INTERVENTION(More)