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Suppression of inflammation by a synthetic histone mimic
Interaction of pathogens with cells of the immune system results in activation of inflammatory gene expression. This response, although vital for immune defence, is frequently deleterious to the hostExpand
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Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly.
Epigenetic gene silencing in eukaryotes is regulated in part by lysine methylation of the core histone proteins. While histone lysine methylation is known to control gene expression through theExpand
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Suppression of the antiviral response by an influenza histone mimic
Viral infection is commonly associated with virus-driven hijacking of host proteins. Here we describe a novel mechanism by which influenza virus affects host cells through the interaction ofExpand
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Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation
Unwinding DNA and unleasing inflammation Fighting infections often comes with collateral damage, which sometimes can be deadly. For instance, in septic shock, the overwhelming release of inflammatoryExpand
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The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity
The nuclear RNA exosome is an essential multi-subunit complex that controls RNA homeostasis. Congenital mutations in RNA exosome genes are associated with neurodegenerative diseases. Little is knownExpand
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Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.
Viruses are obligate parasites and thus require the machinery of the host cell to replicate. Inhibition of host factors co-opted during active infection is a strategy hosts use to suppress viralExpand
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The helicase senataxin suppresses the antiviral transcriptional response and controls viral biogenesis
The human helicase senataxin (SETX) has been linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2). Here we identified a role forExpand
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Inhibiting Inflammation with Myeloid Cell‐Specific Nanobiologics Promotes Organ Transplant Acceptance
&NA; Inducing graft acceptance without chronic immunosuppression remains an elusive goal in organ transplantation. Using an experimental transplantation mouse model, we demonstrate that localExpand
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Influenza virus infection causes global RNAPII termination defects
Viral infection perturbs host cells and can be used to uncover regulatory mechanisms controlling cellular responses and susceptibility to infections. Using cell biological, biochemical, and geneticExpand
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Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection
Summary RNA viruses are a major human health threat. The life cycles of many highly pathogenic RNA viruses like influenza A virus (IAV) and Lassa virus depends on host mRNA, because viral polymerasesExpand
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