Ivan Marazzi

Sort by:

Suppression of inflammation by a synthetic histone mimic.

Edwige Nicodème, Kate L Jeffrey, +14 authors Alexander Tarakhovsky
Nature
2010

Interaction of pathogens with cells of the immune system results in activation of inflammatory gene expression. This response, although vital for immune defence, is frequently deleterious to the host… (More)

Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response.

Simona Saccani, Ivan Marazzi, Amer A. Beg, Gioacchino Natoli
The Journal of experimental medicine
2004

Transcription factors of the nuclear factor (NF)-kappaB/Rel family translocate into the nucleus upon degradation of the IkappaBs. Postinduction repression of NF-kappaB activity depends on… (More)

A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers controls NF-kappaB-dependent gene activity.

Daniela Bosisio, Ivan Marazzi, Alessandra Agresti, Noriaki Shimizu, Marco Bianchi, Gioacchino Natoli
The EMBO journal
2006

Because of its very high affinity for DNA, NF-kappaB is believed to make long-lasting contacts with cognate sites and to be essential for the nucleation of very stable enhanceosomes. However, the… (More)

Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly.

Srihari C. Sampath, Ivan Marazzi, +8 authors Alexander Tarakhovsky
Molecular cell
2007

Epigenetic gene silencing in eukaryotes is regulated in part by lysine methylation of the core histone proteins. While histone lysine methylation is known to control gene expression through the… (More)

Suppression of the antiviral response by an influenza histone mimic.

Ivan Marazzi, Jessica Sze Yin Ho, +11 authors Alexander Tarakhovsky
Nature
2012

Viral infection is commonly associated with virus-driven hijacking of host proteins. Here we describe a novel mechanism by which influenza virus affects host cells through the interaction of… (More)

Interactions of NF-κB with chromatin: the art of being at the right place at the right time

Gioacchino Natoli, Simona Saccani, Daniela Bosisio, Ivan Marazzi
Nature Immunology
2005

Transcription factors of the NF-κB family are essential regulators of the inflammatory and immune responses. The main 'switch' in NF-κB activation is cytoplasmic and leads to the release of NF-κB… (More)

Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.

Nicholas S Heaton, Natasha P Moshkina, +28 authors Ivan Marazzi
Immunity
2016

Viruses are obligate parasites and thus require the machinery of the host cell to replicate. Inhibition of host factors co-opted during active infection is a strategy hosts use to suppress viral… (More)

Degradation of Promoter-bound p65/RelA Is Essential for the Prompt Termination of the Nuclear Factor κB Response

Simona Saccani, Ivan Marazzi, Amer A. Beg, Gioacchino Natoli
The Journal of Experimental Medicine
2004

Transcription factors of the nuclear factor (NF)B/Rel family translocate into the nucleus upon degradation of the I Bs. Postinduction repression of NFB activity depends on NFB– regulated resynthesis… (More)

The helicase senataxin suppresses the antiviral transcriptional response and controls viral biogenesis

Matthew S. Miller, Alexander P Rialdi, +19 authors Ivan Marazzi
Nature Immunology
2015

The human helicase senataxin (SETX) has been linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2). Here we identified a role for… (More)

Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation.

Alex Rialdi, Laura Campisi, +22 authors Ivan Marazzi
Science
2016

The host innate immune response is the first line of defense against pathogens and is orchestrated by the concerted expression of genes induced by microbial stimuli. Deregulated expression of these… (More)

Filter Results:

Publication Year

Publication Type

Co-author

Journals and Conferences

Method