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The transcriptional activators Oct4, Sox2, and Nanog cooperate with a wide array of cofactors to orchestrate an embryonic stem (ES) cell-specific gene expression program that forms the molecular basis of pluripotency. Here, we report using an unbiased in vitro transcription-biochemical complementation assay to discover a multisubunit stem cell coactivator(More)
Several approaches have been introduced to interpret, in terms of high-resolution structure, low-resolution structural data as obtained from cryo-EM. As conformational changes are often observed in biological molecules, these techniques need to take into account the flexibility of proteins. Flexibility has been described in terms of movement between rigid(More)
The diverse transcriptional mechanisms governing cellular differentiation and development of mammalian tissue remains poorly understood. Here we report that TAF7L, a paralogue of TFIID subunit TAF7, is enriched in adipocytes and white fat tissue (WAT) in mouse. Depletion of TAF7L reduced adipocyte-specific gene expression, compromised adipocyte(More)
Brown adipose tissue (BAT) plays an essential role in metabolic homeostasis by dissipating energy via thermogenesis through uncoupling protein 1 (UCP1). Previously, we reported that the TATA-binding protein associated factor 7L (TAF7L) is an important regulator of white adipose tissue (WAT) differentiation. In this study, we show that TAF7L also serves as a(More)
The IR emissivity of human skin is extremly high and measurements of infrared radiation emitted by the skin can be converted directly into accurate temperature value. This process is known as Body IR Thermography. Skin temperature increase associated with increased vascular flow and increased metabolism. In this paper a novel multi-resolution real-time 3D(More)
With recent technological developments, modern computing systems are becoming more and more powerful. Common computers are capable of calculating more than 50,000 million instructions per second. Currently the biggest obstacle in computer usage is slow communication between the human and the computer. With innovation and development of novel (natural based)(More)
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