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The significance of the intermediate (i) region of the Helicobacter pylori vacA gene as a virulence factor associated with the severity of gastric disease is still disputable. The aim of the present study was to evaluate the prevalence and significance of vacA i alleles alone or in combination with other vacA alleles in symptomatic Bulgarian patients and to(More)
The aim of this study was to evaluate Helicobacter pylori antibacterial resistance in 2005 to 2007, resistance evolution since 1996 to 1999, and performance of breakpoint susceptibility testing (BST) compared with E test for clarithromycin or agar dilution method (ADM) for metronidazole, amoxicillin, tetracycline, and ciprofloxacin. Resistance in 613(More)
OBJECTIVE To evaluate the primary, secondary and combined resistance to five antimicrobial agents of 2340 Helicobacter pylori isolates from 19 centers in 10 countries in eastern Europe. METHODS Data were available for centers in Bulgaria, Croatia, the Czech Republic, Estonia, Greece, Lithuania, Poland, Russia, Slovenia and Turkey. Susceptibility was(More)
AIMS To evaluate the activities of six Lactobacillus delbrueckii subsp. bulgaricus (LB) strains against 30 Helicobacter pylori strains by agar-well diffusion method. METHODS AND RESULTS LB cultures [4 x 10(8)-4 x 10(9) CFU ml(-1)) either were prepared in milk at their native pH, 3.8-5.0, or were adjusted to pH 6.4-7.7. At low and neutralized pH, LB(More)
Management of anaerobic infections encompasses surgical procedures, antibacterial therapy and adjuncts. At present, metronidazole, penems, beta-lactam/beta-lactamase inhibitor combinations and chloramphenicol have the highest activity against obligate anaerobes. Tigecycline is a promising new agent. Other antibacterials (e.g., nitazoxanide, moxifloxacin,(More)
Evolution of antibiotic resistance in the anaerobes was reviewed using recent data covering 2000-2013 as compared to previous years. All studies reported growing moxifloxacin resistance in Bacteroides/Parabacteroides spp. in Europe and USA and in Clostridium difficile in Europe. In half or more studies, the resistance rates in Bacteroides/Parabacteroides(More)
AIM The aim of the present study was to evaluate the bactericidal effects of different disinfection methods against microbial biofilms grown in root canals. METHODS A total of 300 freshly-extracted human teeth were infected with microbial pathogens. The biofilm formation and the effects of laser therapy, photodynamic therapy (PDT), iontophoresis, and(More)
The aim of this study was to assess the clinical and socio-demographic risk factors for primary Helicobacter pylori antibacterial resistance. In total, 266 consecutive H. pylori strains, from untreated symptomatic adult patients who answered a questionnaire, were evaluated. Strain susceptibility to amoxicillin, metronidazole, clarithromycin and tetracycline(More)