Learn More
volume 32 NumBeR 8 AuGuST 2014 nature biotechnology Although it may be beneficial for competing industry that no single entity dominates market access to all fundamental iPSC technologies, congestion of patents related to broadly enabling technologies, referred to as a ‘patent thicket’, has the potential to bottleneck innovation. If ownership of overlapping(More)
We have demonstrated the successful production of titanium phosphate glass microspheres in the size range of ∼10-200 μm using an inexpensive, efficient, easily scalable process and assessed their use in bone tissue engineering applications. Glasses of the following compositions were prepared by melt-quench techniques: 0.5P₂O₅-0.4CaO-(0.1-x)Na₂O-xTiO₂, where(More)
Tissue-engineered airways have achieved clinical success, but concerns remain about short-term loss of biomechanical properties, necessitating a stent. This study investigated the effect of chemical-enzymatic decellularization on biochemical properties of trachea important for cell attachment and vascularization (fibronectin and laminin) and cartilage(More)
Induced pluripotent stem cells (iPSCs) have the potential to transform drug discovery and healthcare in the 21(st) century. However, successful commercialization will require standardized manufacturing platforms. Here we highlight the need to define standardized practices for iPSC generation and processing and discuss current challenges to the robust(More)
UNLABELLED Enabling early angiogenesis is a crucial issue in the success of bone tissue engineering. Designing scaffolds with therapeutic potential to stimulate angiogenesis as well as osteogenesis is thus considered a promising strategy. Here, we propose a novel scaffold designed to deliver angiogenic and osteogenic factors in a sequential manner to(More)
BACKGROUND INFORMATION The activation of fibroblasts into myofibroblasts is a crucial event in healing that is linked to remodelling and scar formation, therefore we determined whether regulation of myofibroblast differentiation via integrins might affect wound healing responses in populations of patient-matched HOFs (human oral fibroblasts) compared with(More)
Titanium (Ti) is the material of choice for dental and orthopaedic implants due to its highly biocompatible nature. Modification of the implant surface, either topographically (as roughness) or chemically, can promote accelerated osteogenesis in vivo and greatly increase bone-implant contact and bonding strength. In this paper, we sought to characterise the(More)
Chronic age-related degenerative disorders, including the formation of chronic leg wounds, may occur due to aging of the stromal tissues and ensuing dysfunctional cellular responses. This study investigated the impact of environmental-driven cellular aging on wound healing by conducting a comprehensive analysis of chronic wound fibroblast (CWF) behavior in(More)
OBJECTIVES To determine the gene expression profile characteristic of "guided bone regeneration" associated with a microrough titanium surface. MATERIAL AND METHODS Critical-size calvarial defects were treated with the principle of "guided bone regeneration," whereby the extracranial barriers were either polished (SMO) or microrough (SLA) titanium disks.(More)
Scalable expansion of cells for regenerative cell therapy or to produce large quantities for high-throughput screening remains a challenge for bioprocess engineers. Laboratory scale cell expansion using t-flasks requires frequent passaging that exposes cells to many poorly defined bioprocess forces that can cause damage or alter their phenotype.(More)