Ivan A Kutyrev

  • Citations Per Year
Learn More
Many helminth parasites have evolved strategies to evade the immune response of their hosts, which includes immunomodulation. Prostaglandin E2 (PGE2) is one of the best-described immunomodulators in mammalian helminth parasite infections. We hypothesized that also in teleost fish anti-helminthic immune responses are regulated via PGE2. We used a model(More)
Flavobacterium psychrophilum (Fp) is the causative agent of bacterial cold water disease (BCWD) which causes appreciable economic losses in rainbow trout aquaculture. We previously reported development of a genetic line, designated ARS-Fp-R that exhibits higher survival relative to a susceptible line, designated ARS-Fp-S, following either laboratory or(More)
367 Parasitic worms can survive in the host body for a long time due to their ability to control the immune response. The basic mechanisms underlying the para site’s evasion of the host immune response are antigen mimicry, immunosuppression [1], immunomodula tion [2], and many others. To modulate the host immune system, the parasite is most likely to(More)
Structural organization of mesenteric lymph nodes in the Baikal seal has been studied with regard to its age-dependent changes. It has been shown that the relative area of connective tissue structures (the capsule and trabeculae) increases during postnatal development, while the areas of the cortex and medulla decrease. The proportions of secondary lymph(More)
The composition of leucocytes of the head kidney is studied in the crucian carps (Carassius auratus) either contaminated or uncontaminated with Digramma interrupta. The composition of leucocytes in the pronephros of the crucian carp from Lake Baikal basin has a lymphoid character. Compared to the crucian carp from the European part of Russia, in the fish(More)
For the first time, the potential immunomodulators prostaglandin E2 and γ-aminobutyric acid (GABA) have been revealed in the plerocercoid Diphyllobothrium dendriticum, which is a parasite in the tissues and abdominal cavity of the Baikal omul Coregonus migratorius. The localization of immunomodulators in parasite tissues was compared with the location of(More)
Cellular composition (relative cell content and cell density) of nodules' germinal centers, mantle zones and paracortical zones was evaluated morphometrically in mesenteric lymph nodes of 65 Baikal nerpas (Pusa sibirica Gmelin) aged 1 month-19 years. A significant decrease in the number of large and medium lymphocytes (3 and 1.9 times, respectively) and(More)
Marine foods represent a unique source of poly-unsaturated fatty acids (PUFA) of the omega-3 (n-3) family. Today it is generally accepted that fish oil is important in a healthy and balanced omnivorous human diet. This favorable health perception of fish oil is however troubled by the high level of PUFA oxidation and low absorption in the gastro-intestinal(More)
The morphometric investigation was performed to study the reaction of mast cells (MC) in mucosal lamina propria of hamster duodenum to experimental infection with tapeworm Diphyllobothrium dendriticum. The invasion was found to result in a significant increase of MC cells absolute content, changes in the proportions of their functional groups, increased(More)
A GeXP multiplex, RT-PCR assay was developed and optimized that simultaneously measures expression of a suite of immune-relevant genes in rainbow trout (Oncorhynchus mykiss), concentrating on tumor necrosis factor and interleukin-1 ligand/receptor systems and acute phase response genes. The dataset includes expression values for drpt, il11a, il1b1, il1b2,(More)