Iván De La Pava

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The volume of tissue activated (VTA) is a well-established approach to model the direct effects of deep brain stimulation (DBS) on neural tissue and previous studies have pointed to its potential clinical applications. However, the elevated computational time required to estimate the VTA with standard techniques used in biological neural modeling limits its(More)
Electroporation is an increase of the cell membrane permeability due to the formation of aqueous pores in it when the cell is under the influence of an intense electric field [1][2]. The formation of such pores in the membrane can be used to enhance the uptake of chemotherapeutic drugs into the cell in a cancer treatment known as electrochemotherapy [3]. In(More)
In this work we simulated the diffusion of calcium ions through a nanopore created in the cell membrane by electroporation, in presence and absence of the external electric field responsible of the membrane permeabilization. First we solved the set of coupled differential equations that describe the process of ionic diffusion in a 2D nanopore model using(More)
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