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Recent Advances in Total Synthesis via Metathesis Reactions
The metathesis reactions, in their various versions, have become a powerful and extremely valuable tool for the formation of carbon–carbon bonds in organic synthesis. The plethora of available
Exploring the Ring-Closing Metathesis for the Construction of the Solomonamide Macrocyclic Core: Identification of Bioactive Precursors.
TLDR
Preliminary biological evaluations of the generated solomonamide precursors revealed antitumor activity against various tumor cell lines and the olefin metathesis reaction demonstrated efficiency and validity for the construction of the macrocyclic core.
An Olefin Cross-Metathesis Approach to Depudecin and Stereoisomeric Analogues.
A new total synthesis of the natural product (-)-depudecin, a unique and unexplored histone deacetylase (HDAC) inhibitor, is reported. A key feature of the synthesis is the utilization of an olefin
Chemistry and Biology of Bioactive Glycolipids of Marine Origin
TLDR
In the particular case of glycolipids derived from marine sources, an impressive variety in their structural features and biological properties is observed, thus making them prime targets for chemical synthesis.
Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers.
TLDR
Investigations reveal how minor structural differences in the ligands result in binding with different plasticity of the ZA loop for this difficult-to-drug bromodomain.
Type II-Metacaspases are involved in cell stress but not in cell death in the unicellular green alga Dunaliella tertiolecta
TLDR
Evidence of type II-MCs not being involved in CD in D. tertiolecta is presented, but rather in survival strategies under the stressful irradiance conditions applied in this study.
Exploring the Antiangiogenic Potential of Solomonamide A Bioactive Precursors: In Vitro and In Vivo Evidences of the Inhibitory Activity of Solo F-OH During Angiogenesis
TLDR
The results indicate that Solo F–OH is able to inhibit some key steps of the angiogenic process, including the proliferation, migration, and invasion of endothelial cells, as well as diminish their capability to degrade the extracellular matrix proteins.
Stereoselective Total Synthesis of (-)-Depudecin.
TLDR
The total synthesis of the natural product depudecin, an antiangiogenic microbial polyketide with inhibitory activity against histone deacetylases, is reported, efficiently accomplished by a novel asymmetric methodology of epoxide formation based on a new class of chiral sulfonium salts.
Bengamide Analogues Show A Potent Antitumor Activity against Colon Cancer Cells: A Preliminary Study
TLDR
The biological results render the bengamide analogues Ben I and Ben V as promising antitumoral agents for the treatment of CRC as well as the toxicity of the selected analogues was tested.
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