Iulia Pinzaru

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Propolis is a gum-like product which are gathered by bees from various plants, and which vary in color from light yellow to dark brown. It is known that the propolis have antibacterial, anticarcinogenic, and immunostimulating biological activities. Parts of these activities are probable due to the antioxidative effect of some compounds which occur in(More)
The increased susceptibility of men as compared to women to develop different types of cancer, including skin cancer, is well known; however, the mechanisms involved in this process are still a matter of debate. This study aimed to obtain animal models of photo-chemically-induced skin carcinogenesis by exposure to ultraviolet radiation B (UVB) coupled with(More)
The use of magnetic iron oxide nanoparticles in biomedicine has evolved intensely in the recent years due to the multiple applications of these nanomaterials, mainly in domains like cancer. The aim of the present study was: (i) to develop biocompatible colloidal suspensions based on magnetic iron oxide nanoparticles as future theranostic tools for skin(More)
BACKGROUND Immune system related pathologies affect an increasing number of patients every year, having potentially lethal consequences and requiring expensive and difficult tolerated treatments. This area of pathologies offers an excellent potential for the development of innovative solutions such as nanoformulations; this review aims to describe the main(More)
Cutaneous melanoma is a metastatic disease characterized by high resistance to treatment, the incidence of which has alarmingly increased worldwide over the past years. A thorough characterization of tumor onset, progression and metastasis is compulsory to overcome the gaps existent in melanoma biology. The present study suggests a well‑established protocol(More)
The paper presents a study on the propolis extraction, analysis, nanoencapsulation în β cyclodextrin, and antioxidative activity of both the extracts and micro/nanoparticles. Propolis extraction was realized in various ethanol-water solutions, at room temperature or up to ethanol reflux, and the extracts were analyzed by RP-HPLC. The bioactive compounds(More)
Melanoma is known as the most dangerous form of skin cancer; whereas the malignant choroidal melanoma is an orphan disease known as the most common primary intraocular malignancy in adults. Literature suggests that the consumption of garlic and/or mistletoe leads to a reduced risk of developing cancer. The obtained microstructures present sizes between 1.05(More)
OANA DUICU1#, SORINA CIURLEA2#, CRISTINA DEHELEAN2, SIMONA ARDELEAN3, FLORINA ANDRICA2, DANINA MUNTEAN1, CODRUTA SOICA4, DIANA ANTAL5, , DORINA CORICOVAC2 *, IULIA PINZARU4 1“Victor Babes” University of Medicine and Pharmacy of Timisoara, Department of Pathophysiology, Faculty of Medicine 2 Eftimie Murgu Sq, 300041, Timisoara, Romania 2 “Victor Babes”(More)
COSMIN CITU1#, CORINA DANCIU2#, IULIA PINZARU2, ROXANA GHIULAI2, LAVINIA VLAIA2, VICENTIU VLAIA2, FLORIN BORCAN2*, CATALIN DUMITRU1, IOANA ZINUCA PAVEL2, IOAN SAS1, ELENA BERNAD1 1 “Victor Babes” University of Medicine and Pharmacy Timisoara, Faculty of Medicine, 2nd Eftimie Murgu Sq., 300041, Timisoara, Romania 2 “Victor Babes” University of Medicine and(More)
CONTEXT Oleanolic and ursolic acids are antitumor and antibacterial agents which are extensively studied. Their major disadvantage is the poor water solubility which limits their applications. OBJECTIVES Oleanolic and ursolic acid were encapsulated into polyurethane nanostructures that act as drug carriers. In order to evaluate the effectiveness of the(More)