Iu S Borodkin

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90 patients with alcoholism stage II suffering from secondary affective disorders (anxiety, depression) were divided into 4 groups: treated with GABA-B-receptor ligand baclofen (group 1), with sibazon (group 2), amitriptylin (group 3), placebo (group 4). As shown by clinical, experimental psychological and electrophysiological examinations, baclofen is not(More)
The ethanol-preferring (EP) rats have a higher level of lipid peroxidation in the brain and blood serum than the water-preferring rats. At the same time it was found that EP rats have a decreased antioxidant enzyme activity in the brain tissue (catalase and superoxide dismutase) and blood serum (ceruloplasmin and superoxide dismutase). This antioxidant(More)
The authors have demonstrated the effect of ethimizol on the processes of training and consolidation, the duration of memory traces, and process of reproduction in adult and old mice and rats. It has been found that ethimizol in doses of 1.5-5 mg/kg facilitates the formation of passive avoidance behavior in old animals difficult to be trained and raises the(More)
White rats were divided into water-preferring (WP) and ethanol-preferring (EP) groups, on the basis of their preferable drink: either water or 15% solution of ethanol. Each of these groups was then subdivided into groups which were given to drink for 1 year 15% solution of ethanol (ethanol-treated) or water (controls). Alcohol dehydrogenase/aldehyde(More)
A study was made of the effect of diamide derivatives of imidazole- and pyrazole-dicarboxylic acids on blood glycolysis in rabbits depending on structural and conformational features of the molecules. It was shown that glycolysis is affected by the position and magnitude of an alkyl substituent in the heterocyclic part of the molecule. An essential role in(More)
Activity of alcohol dehydrogenase (ADH) was estimated using highly sensitive spectrophotometric procedure with p-nitrose dimethylaniline as a substrate in blood serum of control healthy persons without a history of alcohol abuse and of the patients with chronic alcoholism. The ADH activity in the control group was about 0.55 +/- 0.04 microM/min/L and in the(More)