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Blood serum and cerebrospinal fluid were studied in 90 patients with multiple sclerosis. Patients showed substantially elevated levels of formaldehyde and N-methyl amino acids as related to control subjects. These metabolites' concentration was also higher in those patients with prevailing cerebellar signs and progressive course of the disease or in(More)
Experiments were made on rats of two lines during 120-140 days. A study was made of the effect of transplanting the embryonal hippocamp tissue and the septum (E 18) on the phenotypically (mechanical destruction in Wistar rats of the areas CA1 and CA4 of the fields of the hippocamp and dentate gyrus) and genotypically (Krushinskiĭ-Molodkina rats, all(More)
The authors present the results of examining 138 patients whose disease could be classed with the so-called "diencephalic epilepsy" proceeding from the structure of the paroxysmal vegetovisceral manifestations, the degree of the neuroendocrinal syndromes, the complicate scope of the organic and functional anomalies, and hydrocephalus of the IIId ventricle.(More)
Using the technique of contrasting the cerebral tissue with phosphotungstic acid, the authors studied the structural and functional status of interneuronal contacts of the molecular layer of the sensomotor cortex in the brain of Krushinsky-Molodkina rats following convulsive sound stimulation and the subsequent audiogenic convulsive paroxysm. Marked(More)
The study of the myelin in the rabbit brain and in biological fluids of patients with multiple sclerosis has revealed the presence of a new highly active proteolytic enzyme. The article describes the physicochemical properties of this enzyme. Its role in the pathogenesis of the demyelinizing process is emphasized: normally being coupled with an inhibitor(More)